Outputs 2003-2012

In the last ten years (2003-2012) the MedInUP members supervised 103 PhD Thesis, and published 380 full manuscripts, 14 books and 48 book chapters (appendix I). A list of published full manuscripts is provided in appendix II.

 

Appendix I -Outputs of MedInUP members

Outputs of MedInUP members

Description

2003

2004

2005

2006

2007

2008

2009

2010

2011

2012

Total

Average

No. of researchers

20

21

22

32

37

40

42

42

46

68

370

37

No. of integrated researchers

17

17

19

20

27

29

33

33

34

33

262

26

No. of technicians and administrative staff

9

9

9

9

9

9

8

10

9

8

89

9

PhD thesis under the supervision of integrated members

4

7

6

10

9

14

10

15

15

13

103

10

Publications in international peer reviewed journals

21

30

29

29

24

39

46

52

59

51

380

38

Books

1

1

1

2

3

3

0

2

1

0

14

1

Book chapters

0

0

0

30

4

2

3

4

3

2

48

5

Models

0

0

0

0

0

0

0

0

0

0

0

0

Patents

0

0

0

0

0

0

0

0

0

3

3

0

Prototypes

0

0

0

0

0

0

0

0

0

0

0

0

Industry research contracts

0

0

0

1

0

0

0

0

0

1

2

0

Research contracts with government bodies

0

0

0

0

0

0

0

0

0

0

0

0

Other research outputs

0

0

0

0

0

0

0

0

0

0

0

0

 

Appendix II - scientific publications by MedInUP members (2003-2012)

ALMEIDA, L. & SOARES-DA-SILVA, P. (2003). Pharmacokinetics and pharmacodynamics of BIA 3-202, a novel COMT inhibitor, during first administration to humans. Drugs R D, 4 (4), 207-17.

ALMEIDA, L. & SOARES-DA-SILVA, P. (2003). Safety, tolerability and pharmacokinetic profile of BIA 2-093, a novel putative antiepileptic agent, during first administration to humans. Drugs R D, 4 (5), 269-84.

ALMEIDA, L. & SOARES-DA-SILVA, P. (2003). Pharmacokinetic and pharmacodynamic profiles of BIA 3-202, a novel catechol-O-methyltransferase (COMT) inhibitor, during multiple-dose administration to healthy subjects. J Clin Pharmacol, 43 (12), 1350-60.

BONIFACIO, M. J. & SOARES-DA-SILVA, P. (2003). Purification of membrane-bound catechol-O-methyltransferase. Methods Mol Biol, 228 231-8.

BONIFACIO, M. J., VIEIRA-COELHO, M. A. & SOARES-DA-SILVA, P. (2003). Kinetic inhibitory profile of BIA 3-202, a novel fast tight-binding, reversible and competitive catechol-O-methyltransferase inhibitor. Eur J Pharmacol, 460 (2-3), 163-70.

COSTA, M. C., MAGALHAES, P., FERREIRINHA, F., GUIMARAES, L., JANUARIO, C., GASPAR, I., LOUREIRO, L., VALE, J., GARRETT, C., REGATEIRO, F., MAGALHAES, M., SOUSA, A., MACIEL, P. & SEQUEIROS, J. (2003). Molecular diagnosis of Huntington disease in Portugal: implications for genetic counselling and clinical practice. Eur J Hum Genet, 11 (11), 872-8.

FARIA, M., OLIVEIRA, L., TIMOTEO, M. A., LOBO, M. G. & CORREIA-DE-SA, P. (2003). Blockade of neuronal facilitatory nicotinic receptors containing alpha 3 beta 2 subunits contribute to tetanic fade in the rat isolated diaphragm. Synapse, 49 (2), 77-88.

GOMES, P. & SOARES-DA-SILVA, P. (2003). Dopamine D2-like receptor-mediated opening of K+ channels in opossum kidney cells. Br J Pharmacol, 138 (5), 968-76.

GUIMARAES, J. T., VINDIS, C., SOARES-DA-SILVA, P. & PARINI, A. (2003). Differential substrate specificity of monoamine oxidase in the rat heart and renal cortex. Life Sci, 73 (8), 955-67.

GUIMARAES, S., MORATO, M., SOUSA, T. & ALBINO-TEIXEIRA, A. (2003). Hypertension due to blockade of adenosine receptors. Pharmacology & Toxicology, 92 (4), 160-162.

LAM, R. S., APP, E. M., NAHIRNEY, D., SZKOTAK, A. J., VIEIRA-COELHO, M. A., KING, M. & DUSZYK, M. (2003). Regulation of Cl- secretion by alpha2-adrenergic receptors in mouse colonic epithelium. J Physiol, 548 (Pt 2), 475-84.

MAGALHAES-CARDOSO, M. T., PEREIRA, M. F., OLIVEIRA, L., RIBEIRO, J. A., CUNHA, R. A. & CORREIA-DE-SA, P. (2003). Ecto-AMP deaminase blunts the ATP-derived adenosine A2A receptor facilitation of acetylcholine release at rat motor nerve endings. J Physiol, 549 (Pt 2), 399-408.

MORATO, M., SOUSA, T., GUIMARAES, S., MOURA, D. & ALBINO-TEIXEIRA, A. (2003). Losartan and atenolol on hypertension induced by adenosine receptor blockade. Auton Autacoid Pharmacol, 23 (2), 133-40.

PALMA, P. N., BONIFACIO, M. J., LOUREIRO, A. I., WRIGHT, L. C., LEARMONTH, D. A. & SOARES-DA-SILVA, P. (2003). Molecular modeling and metabolic studies of the interaction of catechol-O-methyltransferase and a new nitrocatechol inhibitor. Drug Metab Dispos, 31 (3), 250-8.

PARADA, A. & SOARES-DA-SILVA, P. (2003). BIA 3-202, a novel catechol-O-methyltransferase inhibitor, reduces the peripheral O-methylation of L-DOPA and enhances its availability to the brain. Pharmacology, 68 (1), 29-37.

PINHO, M. J., GOMES, P., SERRAO, M. P., BONIFACIO, M. J. & SOARES-DA-SILVA, P. (2003). Organ-specific overexpression of renal LAT2 and enhanced tubular L-DOPA uptake precede the onset of hypertension. Hypertension, 42 (4), 613-8.

REBOLA, N., COELHO, J. E., COSTENLA, A. R., LOPES, L. V., PARADA, A., OLIVEIRA, C. R., SOARES-DA-SILVA, P., DE MENDONCA, A. & CUNHA, R. A. (2003). Decrease of adenosine A1 receptor density and of adenosine neuromodulation in the hippocampus of kindled rats. Eur J Neurosci, 18 (4), 820-8.

SAMPAIO-MAIA, B., SERRAO, P., VIEIRA-COELHO, M. A. & PESTANA, M. (2003). Differences in the renal dopaminergic system activity between Wistar rats from two suppliers. Acta Physiologica Scandinavica, 178 (1), 83-89.

SILVEIRA, P., VAZ-DA-SILVA, M., ALMEIDA, L., MAIA, J., FALCAO, A., LOUREIRO, A., TORRAO, L., MACHADO, R., WRIGHT, L. & SOARES-DA-SILVA, P. (2003). Pharmacokinetic-pharmacodynamic interaction between BIA 3-202, a novel COMT inhibitor, and levodopa/benserazide. Eur J Clin Pharmacol, 59 (8-9), 603-9.

SOARES-DA-SILVA, P., VIEIRA-COELHO, M. A. & PARADA, A. (2003). Catechol-O-methyltransferase inhibition in erythrocytes and liver by BIA 3-202 (1-[3,4-dibydroxy-5-nitrophenyl]-2-phenyl-ethanone). Pharmacol Toxicol, 92 (6), 272-8.

TIMOTEO, M. A., FARIA, M. & CORREIA-DE-SA, P. (2003). Endogenous adenosine prevents post-tetanic release facilitation mediated by alpha3beta2 nicotinic autoreceptors. Eur J Pharmacol, 464 (2-3), 115-25.

ALMEIDA, L. & SOARES-DA-SILVA, P. (2004). Safety, tolerability, and pharmacokinetic profile of BIA 2-093, a novel putative antiepileptic, in a rising multiple-dose study in young healthy humans. J Clin Pharmacol, 44 (8), 906-18.

ALMEIDA, L., VAZ-DA-SILVA, M., SILVEIRA, P., FALCAO, A., MAIA, J., LOUREIRO, A., TORRAO, L., MACHADO, R., WRIGHT, L. & SOARES-DA-SILVA, P. (2004). Pharmacokinetic-pharmacodynamic interaction between BIA 3-202, a novel COMT inhibitor, and levodopa/carbidopa. Clin Neuropharmacol, 27 (1), 17-24.

ALVELOS, M., FERREIRA, A., BETTENCOURT, P., SERRAO, P., PESTANA, M., CERQUEIRA-GOMES, M. & SOARES-DA-SILVA, P. (2004). The effect of dietary sodium restriction on neurohumoral activity and renal dopaminergic response in patients with heart failure. Eur J Heart Fail, 6 (5), 593-9.

ARAUJO, I. M., AMBROSIO, A. F., LEAL, E. C., VERDASCA, M. J., MALVA, J. O., SOARES-DA-SILVA, P., CARVALHO, A. P. & CARVALHO, C. M. (2004). Neurotoxicity induced by antiepileptic drugs in cultured hippocampal neurons: a comparative study between carbamazepine, oxcarbazepine, and two new putative antiepileptic drugs, BIA 2-024 and BIA 2-093. Epilepsia, 45 (12), 1498-505.

DUARTE-ARAUJO, M., NASCIMENTO, C., ALEXANDRINA TIMOTEO, M., MAGALHAES-CARDOSO, T. & CORREIA-DE-SA, P. (2004). Dual effects of adenosine on acetylcholine release from myenteric motoneurons are mediated by junctional facilitatory A(2A) and extrajunctional inhibitory A(1) receptors. Br J Pharmacol, 141 (6), 925-34.

DUARTE-ARAUJO, M., TIMOTEO, M. A. & CORREIA-DE-SA, P. (2004). Adenosine activating A(2A)-receptors coupled to adenylate cyclase/cyclic AMP pathway downregulates nicotinic autoreceptor function at the rat myenteric nerve terminals. Neurochem Int, 45 (5), 641-51.

FERREIRINHA, F., QUATTRINI, A., PIROZZI, M., VALSECCHI, V., DINA, G., BROCCOLI, V., AURICCHIO, A., PIEMONTE, F., TOZZI, G., GAETA, L., CASARI, G., BALLABIO, A. & RUGARLI, E. I. (2004). Axonal degeneration in paraplegin-deficient mice is associated with abnormal mitochondria and impairment of axonal transport. J Clin Invest, 113 (2), 231-42.

FRAGA, S., JOSE, P. A. & SOARES-DA-SILVA, P. (2004). Involvement of G protein-coupled receptor kinase 4 and 6 in rapid desensitization of dopamine D1 receptor in rat IEC-6 intestinal epithelial cells. Am J Physiol Regul Integr Comp Physiol, 287 (4), R772-9.

FRESCO, P., DINIZ, C. & GONCALVES, J. (2004). Facilitation of noradrenaline release by activation of adenosine A(2A) receptors triggers both phospholipase C and adenylate cyclase pathways in rat tail artery. Cardiovasc Res, 63 (4), 739-46.

GOMES, P. & SOARES-DA-SILVA, P. (2004). Dopamine acutely decreases type 3 Na+/H+ exchanger activity in renal OK cells through the activation of protein kinases A and C signalling cascades. Eur J Pharmacol, 488 (1-3), 51-9.

GUIMARAES, S., CARNEIRO, C., BRANDAO, F., PINHEIRO, H., ALBINO-TEIXEIRA, A. & MOURA, D. (2004). A pharmacological differentiation between postjunctional (AT1A) and prejunctional (AT1B) angiotensin II receptors in the rabbit aorta. Naunyn Schmiedebergs Arch Pharmacol, 370 (4), 262-9.

LEARMONTH, D. A., PALMA, P. N., VIEIRA-COELHO, M. A. & SOARES-DA-SILVA, P. (2004). Synthesis, biological evaluation, and molecular modeling studies of a novel, peripherally selective inhibitor of catechol-O-methyltransferase. J Med Chem, 47 (25), 6207-17.

MAGRO, F., ARAUJO, F., PEREIRA, P., MEIRELES, E., DINIZ-RIBEIRO, M. & VELOSOM, F. T. (2004). Soluble selectins, sICAM, sVCAM, and angiogenic proteins in different activity groups of patients with inflammatory bowel disease. Dig Dis Sci, 49 (7-8), 1265-74.

MAGRO, F., FRAGA, S., RIBEIRO, T. & SOARES-DA-SILVA, P. (2004). Intestinal Na+-K+-ATPase activity and molecular events downstream of interferon-gamma receptor stimulation. Br J Pharmacol, 142 (8), 1281-92.

MAGRO, F., FRAGA, S., RIBEIRO, T. & SOARES-DA-SILVA, P. (2004). Decreased availability of intestinal dopamine in transmural colitis may relate to inhibitory effects of interferon-gamma upon L-DOPA uptake. Acta Physiol Scand, 180 (4), 379-86.

MARTEL, F., MONTEIRO, R., LEMOS, C. & VIEIRA-COELHO, M. A. (2004). In vitro and in vivo effect of fluoxetine on the permeability of 3H-serotonin across rat intestine. Can J Physiol Pharmacol, 82 (11), 940-50.

OLIVEIRA, L., TIMOTEO, M. A. & CORREIA-DE-SA, P. (2004). Tetanic depression is overcome by tonic adenosine A(2A) receptor facilitation of L-type Ca(2+) influx into rat motor nerve terminals. J Physiol, 560 (Pt 1), 157-68.

PEDROSA, R., GOMES, P., HOPFER, U., JOSE, P. A. & SOARES-DA-SILVA, P. (2004). Gialpha3 protein-coupled dopamine D3 receptor-mediated inhibition of renal NHE3 activity in SHR proximal tubular cells is a PLC-PKC-mediated event. Am J Physiol Renal Physiol, 287 (5), F1059-66.

PEDROSA, R., GOMES, P. & SOARES-DA-SILVA, P. (2004). Distinct signalling cascades downstream to Gsalpha coupled dopamine D1-like NHE3 inhibition in rat and opossum renal epithelial cells. Cell Physiol Biochem, 14 (1-2), 91-100.

PEDROSA, R., GOMES, P., ZENG, C., HOPFER, U., JOSE, P. A. & SOARES-DA-SILVA, P. (2004). Dopamine D3 receptor-mediated inhibition of Na+/H+ exchanger activity in normotensive and spontaneously hypertensive rat proximal tubular epithelial cells. Br J Pharmacol, 142 (8), 1343-53.

PEDROSA, R., JOSE, P. A. & SOARES-DA-SILVA, P. (2004). Defective D1-like receptor-mediated inhibition of the Cl-/HCO3- exchanger in immortalized SHR proximal tubular epithelial cells. Am J Physiol Renal Physiol, 286 (6), F1120-6.

PESTANA, M., SANTOS, J., SANTOS, A., COROAS, A., CORREIA, F., SERRAO, P., VALBUENA, C. & SOARES-DA-SILVA, P. (2004). Renal dopamine and salt sensitivity of blood pressure in IgA nephropathy. Kidney Blood Press Res, 27 (2), 78-87.

PINHO, D., BESSON, S., BRONDINO, C. D., DE CASTRO, B. & MOURA, I. (2004). Copper-containing nitrite reductase from Pseudomonas chlororaphis DSM 50135. Eur J Biochem, 271 (12), 2361-9.

PINHO, D., BESSON, S., BRONDINO, C. D., PEREIRA, E., DE CASTRO, B. & MOURA, I. (2004). Two azurins with unusual redox and spectroscopic properties isolated from the Pseudomonas chlororaphis strains DSM 50083T and DSM 50135. J Inorg Biochem, 98 (2), 276-86.

PINHO, M. J., SERRAO, M. P., GOMES, P., HOPFER, U., JOSE, P. A. & SOARES-DA-SILVA, P. (2004). Over-expression of renal LAT1 and LAT2 and enhanced L-DOPA uptake in SHR immortalized renal proximal tubular cells. Kidney Int, 66 (1), 216-26.

QUEIROZ, G., QUINTAS, C., TALAIA, C. & GONCALVES, J. (2004). Coupling to protein kinases A and C of adenosine A2B receptors involved in the facilitation of noradrenaline release in the prostatic portion of rat vas deferens. Neuropharmacology, 47 (2), 216-24.

SILVEIRA, P., VAZ-DA-SILVA, M., MAIA, J., ALMEIDA, L., GAMA, H. & SOARES-DA-SILVA, P. (2004). Effects of enalapril and imidapril in the capsaicin cough challange test and spirometry parameters in healthy volunteers. Therapy, 1 (2), 223-230.

SOARES-DA-SILVA, P. & SERRAO, M. P. (2004). High- and low-affinity transport of L-leucine and L-DOPA by the hetero amino acid exchangers LAT1 and LAT2 in LLC-PK1 renal cells. Am J Physiol Renal Physiol, 287 (2), F252-61.

SOARES-DA-SILVA, P., SERRAO, M. P., PINHO, M. J. & BONIFACIO, M. J. (2004). Cloning and gene silencing of LAT2, the L-3,4-dihydroxyphenylalanine (L-DOPA) transporter, in pig renal LLC-PK1 epithelial cells. Faseb J, 18 (13), 1489-98.

SOUSA, T., MORATO, M., FERNANDES, E., CARVALHO, F. & ALBINO-TEIXEIRA, A. (2004). Xanthine oxidase inhibition by 1,3-dipropyl-8-sulfophenylxanthine (DPSPX), an antagonist of adenosine receptors. J Enzyme Inhib Med Chem, 19 (1), 11-5.

ALMEIDA, L., FALCAO, A., MAIA, J., MAZUR, D., GELLERT, M. & SOARES-DA-SILVA, P. (2005). Single-dose and steady-state pharmacokinetics of eslicarbazepine acetate (BIA 2-093) in healthy elderly and young subjects. J Clin Pharmacol, 45 (9), 1062-6.

ALVELOS, M., FERREIRA, A., BETTENCOURT, P., PIMENTA, J., AZEVEDO, A., SERRAO, P., ROCHA-GONCALVES, F. & SOARES-DA-SILVA, P. (2005). Effect of saline load and metoclopramide on the renal dopaminergic system in patients with heart failure and healthy controls. J Cardiovasc Pharmacol, 45 (3), 197-203.

DIAS, A. G., LOPES, M. A., TRIGO CABRAL, A. T., SANTOS, J. D. & FERNANDES, M. H. (2005). In vitro studies of calcium phosphate glass ceramics with different solubility with the use of human bone marrow cells. J Biomed Mater Res A, 74 (3), 347-55.

FONTES-RIBEIRO, C., NUNES, T., FALCAO, A., NETA, C., LIMA, R., TAVARES, S., ALMEIDA, L., MACEDO, T. & SOARES-DA-SILVA, P. (2005). Eslicarbazepine acetate (BIA 2-093) : relative bioavailability and bioequivalence of 50 mg/mL oral suspension and 200mg and 800mg tablet formulations. Drugs R D, 6 (5), 253-60.

FRAGA, S., PINHO, M. J. & SOARES-DA-SILVA, P. (2005). Expression of LAT1 and LAT2 amino acid transporters in human and rat intestinal epithelial cells. Amino Acids, 29 (3), 229-33.

GOMES, P. & SOARES-DA-SILVA, P. (2005). Up-regulation of apical NHE3 in renal OK cells overexpressing the rodent {alpha}1- subunit of the Na+ pump. Am J Physiol Regul Integr Comp Physiol, 290 R1142-R1150.

GUIMARAES, S. & PINHEIRO, H. (2005). Functional evidence that in the cardiovascular system AT1 angiotensin II receptors are AT1B prejunctionally and AT1A postjunctionally. Cardiovasc Res, 67 (2), 208-15.

LEARMONTH, D. A., BONIFACIO, M. J. & SOARES-DA-SILVA, P. (2005). Synthesis and Biological Evaluation of a Novel Series of "Ortho-Nitrated" Inhibitors of Catechol-O-methyltransferase. J Med Chem, 48 (25), 8070-8.

MAGINA, S., SANTOS, J., COROAS, A., OLIVEIRA, J. G., SERRAO, P., SOARES-DA-SILVA, P., RESENDE, C. & PESTANA, M. (2005). Salt sensitivity of blood pressure in patients with psoriasis on ciclosporin therapy. Br J Dermatol, 152 (4), 773-6.

MAGRO, F., FRAGA, S., RIBEIRO, T. & SOARES-DA-SILVA, P. (2005). Regional intestinal adaptations in Na+,K+-ATPase in experimental colitis and the contrasting effects of interferon-gamma. Acta Physiol Scand, 183 (2), 191-9.

MAGRO, F., FRAGA, S. & SOARES-DA-SILVA, P. (2005). Interferon-gamma-induced STAT1-mediated membrane retention of NHE1 and associated proteins ezrin, radixin and moesin in HT-29 cells. Biochem Pharmacol, 70 (9), 1312-9.

MAGRO, F., FRAGA, S. & SOARES-DA-SILVA, P. (2005). Signaling of short- and long-term regulation of intestinal epithelial type 1 Na+/H+ exchanger by interferon-gamma. Br J Pharmacol, 145 (1), 93-103.

MAGRO, F., PEREIRA, P., CARNEIRO, F., LOPES, J., TEIXEIRA, A., SARMENTO, C., LIMA, J., SARAIVA, A., TEIXEIRA, A. & TAVARELA-VELOSO, F. (2005). Colon stenosis in a patient with ulcerative colitis as a manifestation of mixed mullerian tumor of the peritoneum. Scand J Gastroenterol, 40 (10), 1251-4.

MAGRO, F., PEREIRA, P., CARNEIRO, F. & VELOSO, F. T. (2005). Reactive hepatitis in a patient with Crohn's disease successfully treated with infliximab: does tumor necrosis factor alpha play a role in reactive hepatitis? Inflamm Bowel Dis, 11 (1), 88-90.

MAGRO, F., PEREIRA, P., VELOSO, F. T. & CARNEIRO, F. (2005). Unusual presentation of tuberculosis after infliximab therapy. Inflamm Bowel Dis, 11 (1), 82-4.

MAIA, J., VAZ-DA-SILVA, M., ALMEIDA, L., FALCAO, A., SILVEIRA, P., GUIMARAES, S., GRAZIELA, P. & SOARES-DA-SILVA, P. (2005). Effect of food on the pharmacokinetic profile of eslicarbazepine acetate (BIA 2-093). Drugs R D, 6 (4), 201-6.

MERGULHAO, P., MAGRO, F., PEREIRA, P., CORREIA, R., LOPES, J. M., MAGALHAES, J., DIAS, J. M., CARNEIRO, F. & TAVARELA-VELOSO, F. (2005). Gingival hyperplasia as a first manifestation of Crohn's disease. Dig Dis Sci, 50 (10), 1946-9.

MOURA, E., PINHO COSTA, P. M., MOURA, D., GUIMARAES, S. & VIEIRA-COELHO, M. A. (2005). Decreased tyrosine hydroxylase activity in the adrenals of spontaneously hypertensive rats. Life Sci, 76 (25), 2953-64.

OLIVEIRA, L. & CORREIA-DE-SA, P. (2005). Protein kinase A and Ca(v)1 (L-Type) channels are common targets to facilitatory adenosine A2A and muscarinic M1 receptors on rat motoneurons. Neurosignals, 14 (5), 262-72.

PINHO, D., BESSON, S., SILVA, P. J., DE CASTRO, B. & MOURA, I. (2005). Isolation and spectroscopic characterization of the membrane-bound nitrate reductase from Pseudomonas chlororaphis DSM 50135. Biochim Biophys Acta, 1723 (1-3), 151-62.

REBOLA, N., PORCIUNCULA, L. O., LOPES, L. V., OLIVEIRA, C. R., SOARES-DA-SILVA, P. & CUNHA, R. A. (2005). Long-term effect of convulsive behavior on the density of adenosine A1 and A 2A receptors in the rat cerebral cortex. Epilepsia, 46 Suppl 5 159-65.

RODRIGUES, M. L., BONIFACIO, M. J., SOARES-DA-SILVA, P., CARRONDO, M. A. & ARCHER, M. (2005). Crystallization and preliminary X-ray diffraction studies of a catechol-O-methyltransferase/inhibitor complex. Acta Crystallograph Sect F Struct Biol Cryst Commun, 61 (Pt 1), 118-120.

SAMPAIO-MAIA, B., MOREIRA-RODRIGUES, M., SERRAO, P. & PESTANA, M. (2005). Jejunal dopamine and Na,K+-ATPase activity in nephrotic syndrome. Am J Nephrol, 25 (4), 382-92.

SAMPAIO-MAIA, B., SERRAO, P., GUIMARAES, J. T., VIEIRA-COELHO, M. A. & PESTANA, M. (2005). Renal dopaminergic system activity in the rat remnant kidney. Nephron Exp Nephrol, 99 (2), e46-55.

SHIROSAKI, Y., TSURU, K., HAYAKAWA, S., OSAKA, A., LOPES, M. A., SANTOS, J. D. & FERNANDES, M. H. (2005). In vitro cytocompatibility of MG63 cells on chitosan-organosiloxane hybrid membranes. Biomaterials, 26 (5), 485-93.

SOARES-DA-SILVA, P. & SERRAO, M. P. (2005). Apical and basolateral 4F2hc and the amino acid exchange of L-DOPA in renal LLC-PK(1) cells. Amino Acids, 29 (3), 213-9.

SOARES-DA-SILVA, P., SERRAO, P., FRAGA, S. & PINHO, M. J. (2005). Expression and function of LAT1, a neutral amino acid exchanger, in renal porcine epithelial cell line LLC-PK. Acta Physiol Scand, 185 (1), 71-8.

SOUSA, T., FERNANDES, E., NUNES, C., LARANJINHA, J., CARVALHO, F., PINHO, D., MORATO, M. & ALBINO-TEIXEIRA, A. (2005). Scavenging of nitric oxide by an antagonist of adenosine receptors. J Pharm Pharmacol, 57 (3), 399-404.

VAZ-DA-SILVA, M., LOUREIRO, A. I., NUNES, T., MAIA, J., TAVARES, S., FALCAO, A., SILVEIRA, P., ALMEIDA, L. & SOARES-DA-SILVA, P. (2005). Bioavailability and bioequivalence of two enteric-coated formulations of omeprazole in fasting and fed conditions. Clin Drug Investig, 25 (6), 391-9.

ARAUJO, C. S., ALBUQUERQUE, R. R., JR., RODRIGUES, M. M., MAIA, B. S., MOREIRA, A. F. & PESTANA, M. (2006). Medullar expression of type-A natriuretic peptide receptor in an animal model of hypertension induced by renal mass ablation. Rev Port Cardiol, 25 (4), 419-27.

BEK, M. J., WANG, X., ASICO, L. D., JONES, J. E., ZHENG, S., LI, X., EISNER, G. M., GRANDY, D. K., CAREY, R. M., SOARES-DA-SILVA, P. & JOSE, P. A. (2006). Angiotensin-II type 1 receptor-mediated hypertension in D4 dopamine receptor-deficient mice. Hypertension, 47 (2), 288-95.

BELIAEV, A., LEARMONTH, D. A. & SOARES-DA-SILVA, P. (2006). Synthesis and biological evaluation of novel, peripherally selective chromanyl imidazolethione-based inhibitors of dopamine beta-hydroxylase. J Med Chem, 49 (3), 1191-1197.

CAVADAS, C., CEFAI, D., ROSMANINHO-SALGADO, J., VIEIRA-COELHO, M. A., MOURA, E., BUSSO, N., PEDRAZZINI, T., GRAND, D., ROTMAN, S., WAEBER, B., AUBERT, J. F. & GROUZMANN, E. (2006). Deletion of the neuropeptide Y (NPY) Y1 receptor gene reveals a regulatory role of NPY on catecholamine synthesis and secretion. Proc Natl Acad Sci U S A, 103 (27), 10497-502.

CORDEIRO, J. M., DUNANT, Y. & GONCALVES, P. P. (2006). Vesicular calcium transport shapes rapid acetylcholine secretion. J Mol Neurosci, 30 (1-2), 41-4.

CORREIA-DE-SA, P., ADAES, S., TIMOTEO, M. A., VIEIRA, C., MAGALHAES-CARDOSO, T., NASCIMENTO, C. & DUARTE-ARAUJO, M. (2006). Fine-tuning modulation of myenteric motoneurons by endogenous adenosine: on the role of secreted adenosine deaminase. Auton Neurosci, 126-127 211-24.

COSTA, J., LOBO, M. G. & CORREIA-DE-SA, P. (2006). Paradoxical nifedipine facilitation of 45Ca uptake into rat hippocampal synaptosomes. Eur J Pharmacol, 544 (1-3), 39-48.

FRAGA, S., LUO, Y., JOSE, P., ZANDI-NEJAD, K., MOUNT, D. B. & SOARES-DA-SILVA, P. (2006). Dopamine D1-like receptor-mediated inhibition of Cl/HCO3- exchanger activity in rat intestinal epithelial IEC-6 cells is regulated by G protein-coupled receptor kinase 6 (GRK 6). Cell Physiol Biochem, 18 (6), 347-360.

FRESCO, P., BORGES, F., DINIZ, C. & MARQUES, M. P. (2006). New insights on the anticancer properties of dietary polyphenols. Med Res Rev, 26 (6), 747-66.

GOMES, P. & SOARES-DA-SILVA, P. (2006). Upregulation of apical NHE3 in renal OK cells overexpressing the rodent alpha(1)-subunit of the Na+ pump. Am J Physiol Regul Integr Comp Physiol, 290 (4), R1142-R1150.

LOUREIRO, A. I., BONIFACIO, M. J., FERNANDES-LOPES, C., ALMEIDA, L., WRIGHT, L. C. & SOARES-DA-SILVA, P. (2006). Human metabolism of nebicapone (BIA 3-202), a novel catechol-o-methyltransferase inhibitor: characterization of in vitro glucuronidation. Drug Metab Dispos, 34 (11), 1856-1862.

MAGRO, F. & COSTA, C. (2006). Long-standing remission of Crohn's disease under imatinib therapy in a patient with Crohn's disease. Inflamm Bowel Dis, 12 (11), 1087-9.

MAGRO, F., CUNHA, E., ARAUJO, F., MEIRELES, E., PEREIRA, P., DINIS-RIBEIRO, M., VELOSO, F. T., MEDEIROS, R. & SOARES-DA-SILVA, P. (2006). Dopamine D2 receptor polymorphisms in inflammatory bowel disease and the refractory response to treatment. Dig Dis Sci, 51 (11), 2039-2044.

MAGRO, F., FRAGA, S., AZEVEDO, I. & SOARES-DA-SILVA, P. (2006). Intestinal 5-hydroxytryptamine and mast cell infiltration in rat experimental colitis. Dig Dis Sci, 51 (3), 495-501.

MORATO, M., PINHO, D., SOUSA, T., GUIMARAES, S., MOURA, D. & ALBINO-TEIXEIRA, A. (2006). Pre- and postjunctional effects of angiotensin II in hypertension due to adenosine receptor blockade. Eur J Pharmacol, 531 (1-3), 209-216.

MORATO, M., PINHO, D., SOUSA, T., TAVARES, I. & ALBINO-TEIXEIRA, A. (2006). Inhibition of nociceptive responses of spinal cord neurones during hypertension involves the spinal GABAergic system and a pain modulatory center located at the caudal ventrolateral medulla. J Neurosci Res, 83 (4), 647-55.

MOURA, E., AFONSO, J., HEIN, L. & VIEIRA-COELHO, M. A. (2006). Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice. Br J Pharmacol, 149 (8), 1049-58.

OLIVEIRA, J. M., CHEN, S., ALMEIDA, S., RILEY, R., GONCALVES, J., OLIVEIRA, C. R., HAYDEN, M. R., NICHOLLS, D. G., ELLERBY, L. M. & REGO, A. C. (2006). Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: effect of histone deacetylase inhibitors. J Neurosci, 26 (43), 11174-86.

OLIVEIRA, L. & CORREIA-DE SA, P. (2006). Dissociation between M1-facilitation of acetylcholine release and crosstalk with A2A- and M2-receptors on rat motoneurons. Signal Transduction, 6 (1), 19-31.

PALMA, P. N., RODRIGUES, M. L., ARCHER, M., BONIFACIO, M. J., LOUREIRO, A. I., LEARMONTH, D. A., CARRONDO, M. A. & SOARES-DA-SILVA, P. (2006). Comparative study of ortho- and meta-nitrated inhibitors of catechol-O-methyltransferase: interactions with the active site and regioselectivity of O-methylation. Mol Pharmacol, 70 (1), 143-153.

PINHO, D., SOUSA, T., MORATO, M., TAVARES, I. & ALBINO-TEIXEIRA, A. (2006). Lesion of the caudal ventrolateral medulla prevents the induction of hypertension by adenosine receptor blockade in rats. Brain Res, 1073-1074 374-82.

SAMPAIO-MAIA, B., MOREIRA-RODRIGUES, M. & PESTANA, M. (2006). Role of chronic inhibition of dopamine-metabolizing enzymes in the regulation of renal sodium and phosphate excretion in the rat remnant kidney. Nephron Physiol, 103 (1), 14-24.

SAMPAIO-MAIA, B., MOREIRA-RODRIGUES, M., SERRAO, P. & PESTANA, M. (2006). Blunted renal dopaminergic system activity in puromycin aminonucleoside-induced nephrotic syndrome. Nephrol Dial Transplant, 21 (2), 314-23.

SAMPAIO-MAIA, B., MOREIRA-RODRIGUES, M., SERRAO, P. & PESTANA, M. (2006). Blunted renal dopaminergic system activity in HgCl(2)-induced membranous nephropathy. Life Sci, 78 (11), 1246-55.

SAMPAIO-MAIA, B., SERRAO, P., MOURA, M. & PESTANA, M. (2006). Jejunal dopamine and Na,K-ATPase activity in early chronic renal insufficiency. Nephrology (Carlton), 11 (1), 63-7.

SILVA, E., GOMES, P. & SOARES-DA-SILVA, P. (2006). Increases in transepithelial vectorial Na+ transport facilitates Na+-dependent L-DOPA transport in renal OK cells. Life Sci, 79 (8), 723-729.

SILVA, E., GOMES, P. & SOARES-DA-SILVA, P. (2006). Overexpression of Na(+)/K (+)-ATPase parallels the increase in sodium transport and potassium recycling in an in vitro model of proximal tubule cellular ageing. J Membr Biol, 212 (3), 163-75.

TALAIA, C., QUEIROZ, G., PINHEIRO, H., MOURA, D. & GONCALVES, J. (2006). Involvement of G-protein beta gamma subunits on the influence of inhibitory alpha(2)-autoreceptors on the angiotensin AT(1)-receptor modulation of noradrenaline release in the rat vas deferens. Neurochemistry International, 49 (7), 698-707.

TROTT, A., JARDIM, L. B., LUDWIG, H. T., SAUTE, J. A., ARTIGALAS, O., KIELING, C., WANDERLEY, H. Y., RIEDER, C. R., MONTE, T. L., SOCAL, M., ALONSO, I., FERRO, A., CARVALHO, T., DO CEU MOREIRA, M., MENDONCA, P., FERREIRINHA, F., SILVEIRA, I., SEQUEIROS, J., GIUGLIANI, R. & SARAIVA-PEREIRA, M. L. (2006). Spinocerebellar ataxias in 114 Brazilian families: clinical and molecular findings. Clin Genet, 70 (2), 173-6.

ALMEIDA, L., AZEVEDO, B., NUNES, T., VAZ-DA-SILVA, M. & SOARES-DA-SILVA, P. (2007). Why healthy subjects volunteer for phase I studies and how they perceive their participation? Eur J Clin Pharmacol, 63 (11), 1085-94.

ALMEIDA, L. & SOARES-DA-SILVA, P. (2007). Eslicarbazepine acetate (BIA 2-093). Neurotherapeutics, 4 (1), 88-96.

BARROSO, A., OLIVEIRA, L., CAMPESATTO-MELLA, E., SILVA, C., TIMOTEO, M. A., MAGALHAES-CARDOSO, M. T., ALVES-DO-PRADO, W. & CORREIA-DE-SA, P. (2007). L-citrulline inhibits [3H]acetylcholine release from rat motor nerve terminals by increasing adenosine outflow and activation of A1 receptors. Br J Pharmacol, 151 (4), 541-50.

BONIFACIO, M. J., PALMA, P. N., ALMEIDA, L. & SOARES-DA-SILVA, P. (2007). Catechol-O-methyltransferase and its inhibitors in Parkinson's disease. CNS Drug Rev, 13 (3), 352-79.

CABRAL, C. T. & FERNANDES, M. H. (2007). In vitro comparison of chlorhexidine and povidone-iodine on the long-term proliferation and functional activity of human alveolar bone cells. Clin Oral Investig, 11 (2), 155-64.

CABRAL, M. C., COSTA, M. A. & FERNANDES, M. H. (2007). In vitro models of periodontal cells: a comparative study of long-term gingival, periodontal ligament and alveolar bone cell cultures in the presence of beta-glycerophosphate and dexamethasone. J Mater Sci Mater Med, 18 (6), 1079-88.

DAMASCENO-OLIVEIRA, A., FERNANDEZ-DURAN, B., GONCALVES, J., SERRAO, P., SOARES-DA-SILVA, P., REIS-HENRIQUES, M. A. & COIMBRA, J. (2007). Effects of cyclic hydrostatic pressure on the brain biogenic amines concentrations in the flounder, Platichthys flesus. Gen Comp Endocrinol, 153 (1-3), 385-9.

ELGER, C., BIALER, M., CRAMER, J. A., MAIA, J., ALMEIDA, L. & SOARES-DA-SILVA, P. (2007). Eslicarbazepine acetate: a double-blind, add-on, placebo-controlled exploratory trial in adult patients with partial-onset seizures. Epilepsia, 48 (3), 497-504.

FALCAO, A., MAIA, J., ALMEIDA, L., MAZUR, D., GELLERT, M. & SOARES-DA-SILVA, P. (2007). Effect of gender on the pharmacokinetics of eslicarbazepine acetate (BIA 2-093), a new voltage-gated sodium channel blocker. Biopharm Drug Dispos, 28 (5), 249-56.

FRESCO, P., OLIVEIRA, J. M., KUNC, F., SOARES, A. S., ROCHA-PEREIRA, C., GONCALVES, J. & DINIZ, C. (2007). A2A adenosine-receptor-mediated facilitation of noradrenaline release in rat tail artery involves protein kinase C activation and betagamma subunits formed after alpha2-adrenoceptor activation. Neurochem Int, 51 (1), 47-56.

GILSBACH, R., BREDE, M., BEETZ, N., MOURA, E., MUTHIG, V., GERSTNER, C., BARRETO, F., NEUBAUER, S., VIEIRA-COELHO, M. A. & HEIN, L. (2007). Heterozygous alpha 2C-adrenoceptor-deficient mice develop heart failure after transverse aortic constriction. Cardiovasc Res, 75 (4), 728-37.

GOMES, P. S. & FERNANDES, M. H. (2007). Effect of therapeutic levels of doxycycline and minocycline in the proliferation and differentiation of human bone marrow osteoblastic cells. Arch Oral Biol, 52 (3), 251-9.

MAGRO, F., FRAGA, S. & SOARES-DA-SILVA, P. (2007). Short-term effect on intestinal epithelial Na(+)/H(+) exchanger by Gi(alpha1,2)-coupled 5-HT(1A) and G(q/11)-coupled 5-HT(2) receptors. Life Sci, 81 (7), 560-9.

MOREIRA-RODRIGUES, M., RONCON-ALBUQUERQUE, R., JR., HENRIQUES-COELHO, T., LOURENCO, A. P., SAMPAIO-MAIA, B., SANTOS, J., PESTANA, M. & LEITE-MOREIRA, A. F. (2007). Cardiac remodeling and dysfunction in nephrotic syndrome. Kidney Int, 71 (12), 1240-8.

MOREIRA-RODRIGUES, M., SAMPAIO-MAIA, B., MOURA, M. & PESTANA, M. (2007). Renal dopaminergic system activity in uninephrectomized rats up to 26 weeks after surgery. Am J Nephrol, 27 (3), 232-9.

OLIVEIRA, J. M., JEKABSONS, M. B., CHEN, S., LIN, A., REGO, A. C., GONCALVES, J., ELLERBY, L. M. & NICHOLLS, D. G. (2007). Mitochondrial dysfunction in Huntington's disease: the bioenergetics of isolated and in situ mitochondria from transgenic mice. J Neurochem, 101 (1), 241-9.

PEDROSA, R., GONCALVES, N., HOPFER, U., JOSE, P. A. & SOARES-DA-SILVA, P. (2007). Activity and regulation of Na+-HCO3- cotransporter in immortalized spontaneously hypertensive rat and Wistar-Kyoto rat proximal tubular epithelial cells. Hypertension, 49 (5), 1186-93.

PINHO, D., MORATO, M., SOUSA, T., MARQUES-LOPES, J., TAVARES, I. & ALBINO-TEIXEIRA, A. (2007). Hipertensão e hipoalgesia: papel do bolbo raquidiano ventrolateral caudal e do sistema GABAérgico espinhal. Dor, 15 (2), 13-21.

PINHO, M. J., PINTO, V., SERRAO, M. P., JOSE, P. A. & SOARES-DA-SILVA, P. (2007). Underexpression of the Na+-dependent neutral amino acid transporter ASCT2 in the spontaneously hypertensive rat kidney. Am J Physiol Regul Integr Comp Physiol, 293 (1), R538-47.

PINHO, M. J., SERRAO, M. P., JOSE, P. A. & SOARES-DA-SILVA, P. (2007). Overexpression of non-functional LAT1/4F2hc in renal proximal tubular epithelial cells from the spontaneous hypertensive rat. Cell Physiol Biochem, 20 (5), 535-48.

PINHO, M. J., SERRAO, M. P., JOSE, P. A. & SOARES-DA-SILVA, P. (2007). Organ specific underexpression renal of Na+-dependent B0AT1 in the SHR correlates positively with overexpression of NHE3 and salt intake. Mol Cell Biochem, 306 (1-2), 9-18.

PINHO, M. J., SERRAO, M. P. & SOARES-DA-SILVA, P. (2007). High-salt intake and the renal expression of amino acid transporters in spontaneously hypertensive rats. Am J Physiol Renal Physiol, 292 (5), F1452-63.

SILVA, E. & SOARES-DA-SILVA, P. (2007). Reactive oxygen species and the regulation of renal Na+-K+-ATPase in opossum kidney cells. Am J Physiol Regul Integr Comp Physiol, 293 (4), R1764-70.

SILVA, V. S., NUNES, M. A., CORDEIRO, J. M., CALEJO, A. I., SANTOS, S., NEVES, P., SYKES, A., MORGADO, F., DUNANT, Y. & GONCALVES, P. P. (2007). Comparative effects of aluminum and ouabain on synaptosomal choline uptake, acetylcholine release and (Na+/K+)ATPase. Toxicology, 236 (3), 158-77.

ALMEIDA, L., COELHO, R., ALBINO-TEIXEIRA, A. & SOARES-DA-SILVA, P. (2008). Adverse non-drug-related complaints by healthy volunteers in Phase I studies compared to the healthy general population. Int J Clin Pharmacol Ther, 46 (11), 574-583.

ALMEIDA, L., FALCAO, A., COELHO, R., ALBINO-TEIXEIRA, A. & SOARES-DA-SILVA, P. (2008). The role of socioeconomic conditions and psychological factors in the willingness to volunteer for Phase I studies. Pharm Med, 22 (6), 367-74.

ALMEIDA, L., FALCAO, A., VAZ-DA-SILVA, M., COELHO, R., ALBINO-TEIXEIRA, A. & SOARES-DA-SILVA, P. (2008). Personality characteristics of volunteers in Phase 1 studies and likelihood of reporting adverse events. Int J Clin Pharmacol Ther, 46 (7), 340-348.

ALMEIDA, L., FALCAO, A., VAZ-DA-SILVA, M., NUNES, T., SANTOS, A. T., ROCHA, J. F., NETA, C., MACEDO, T., FONTES-RIBEIRO, C. & SOARES-DA-SILVA, P. (2008). Effect of nebicapone on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Eur J Clin Pharmacol, 64 (10), 961-966.

ALMEIDA, L., KASHDAN, T. B., COELHO, R., ALBINO-TEIXEIRA, A. & SOARES-DA-SILVA, P. (2008). Healthy subjects volunteering for Phase I studies: influence of curiosity, exploratory tendencies and perceived self-efficacy. Int J Clin Pharmacol Ther, 46 (3), 109-18.

ALMEIDA, L., KASHDAN, T. B., NUNES, T., COELHO, R., ALBINO-TEIXEIRA, A. & SOARES-DA-SILVA, P. (2008). Who volunteers for phase I clinical trials? Influences of anxiety, social anxiety and depressive symptoms on self-selection and the reporting of adverse events. Eur J Clin Pharmacol, 64 (6), 575-82.

ALMEIDA, L., MINCIU, I., NUNES, T., BUTOIANU, N., FALCAO, A., MAGUREANU, S. A. & SOARES-DA-SILVA, P. (2008). Pharmacokinetics, efficacy, and tolerability of eslicarbazepine acetate in children and adolescents with epilepsy. J Clin Pharmacol, 48 (8), 966-977.

ALMEIDA, L., POTGIETER, J. H., MAIA, J., POTGIETER, M. A., MOTA, F. & SOARES-DA-SILVA, P. (2008). Pharmacokinetics of eslicarbazepine acetate in patients with moderate hepatic impairment. Eur J Clin Pharmacol, 64 (3), 267-273.

ALVES, G., FIGUEIREDO, I., CASTEL-BRANCO, M., LOURENCO, N., FALCAO, A., CARAMONA, M. & SOARES-DA-SILVA, P. (2008). Disposition of eslicarbazepine acetate in the mouse after oral administration. Fundam Clin Pharmacol, 22 (5), 529-536.

ALVES, G., FIGUEIREDO, I., FALCAO, A., CASTEL-BRANCO, M., CARAMONA, M. & SOARES-DA-SILVA, P. (2008). Stereoselective disposition of S- and R-licarbazepine in mice. Chirality, 20 (6), 796-804.

AMARAL, J. S., PINHO, M. J. & SOARES-DA-SILVA, P. (2008). Genomic regulation of intestinal amino acid transporters by aldosterone. Mol Cell Biochem, 313 (1-2), 1-10.

AMARAL, M., DIAS, A. G., GOMES, P. S., LOPES, M. A., SILVA, R. F., SANTOS, J. D. & FERNANDES, M. H. (2008). Nanocrystalline diamond: In vitro biocompatibility assessment by MG63 and human bone marrow cells cultures. J Biomed Mater Res A, 87 (1), 91-9.

AMARAL, M., GOMES, P. S., LOPES, M. A., SANTOS, J. D., SILVA, R. F. & FERNANDES, M. H. (2008). Nanocrystalline diamond as a coating for joint implants: Cytotoxicity and biocompatibility assessment. J Nanomaterials,

CHAVES, S., GIL, M., CANARIO, S., JELIC, R., ROMAO, M. J., TRINCAO, J., HERDTWECK, E., SOUSA, J., DINIZ, C., FRESCO, P. & SANTOS, M. A. (2008). Biologically relevant O,S-donor compounds. Synthesis, molybdenum complexation and xanthine oxidase inhibition. Dalton Trans, (13), 1773-82.

DINIZ, C., BORGES, F., SANTANA, L., URIARTE, E., OLIVEIRA, J. M., GONCALVES, J. & FRESCO, P. (2008). Ligands and therapeutic perspectives of adenosine A(2A) receptors. Curr Pharm Des, 14 (17), 1698-722.

FARIA, M., MAGALHAES-CARDOSO, T., LAFUENTE-DE-CARVALHO, J. M. & CORREIA-DE SA, P. (2008). Decreased ecto-NTPDase1/CD39 activity leads to desensitization of P2 purinoceptors regulating tonus of corpora cavernosa in impotent men with endothelial dysfunction. Nucleosides Nucleotides Nucleic Acids, 27 (6), 761-8.

FERREIRA, J. J., ALMEIDA, L., CUNHA, L., TICMEANU, M., ROSA, M. M., JANUARIO, C., MITU, C. E., COELHO, M., CORREIA-GUEDES, L., MORGADINHO, A., NUNES, T., WRIGHT, L. C., FALCAO, A., SAMPAIO, C. & SOARES-DA-SILVA, P. (2008). Effects of nebicapone on levodopa pharmacokinetics, catechol-O-methyltransferase activity, and motor fluctuations in patients with Parkinson disease. Clin Neuropharmacol, 31 (1), 2-18.

FONTES-RIBEIRO, C., MACEDO, T., NUNES, T., NETA, C., VASCONCELOS, T., CERDEIRA, R., LIMA, R., ROCHA, J. F., FALCAO, A., ALMEIDA, L. & SOARES-DA-SILVA, P. (2008). Dosage form proportionality and food effect of the final tablet formulation of eslicarbazepine acetate: randomized, open-label, crossover, single-centre study in healthy volunteers. Drugs R D, 9 (6), 447-454.

GOMES, P. S., SANTOS, J. D. & FERNANDES, M. H. (2008). Cell-induced response by tetracyclines on human bone marrow colonized hydroxyapatite and Bonelike. Acta Biomater, 4 (3), 630-7.

LEAL, S., SA, C., GONCALVES, J., FRESCO, P. & DINIZ, C. (2008). Immunohistochemical characterization of adenosine receptors in rat aorta and tail arteries. Microsc Res Tech, 71 (10), 703-9.

LI, H., ARMANDO, I., YU, P., ESCANO, C., MUELLER, S. C., ASICO, L., PASCUA, A., LU, Q., WANG, X., VILLAR, V. A., JONES, J. E., WANG, Z., PERIASAMY, A., LAU, Y. S., SOARES-DA-SILVA, P., CRESWELL, K., GUILLEMETTE, G., SIBLEY, D. R., EISNER, G., GILDEA, J. J., FELDER, R. A. & JOSE, P. A. (2008). Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells. J Clin Invest, 118 (6), 2180-9.

MAGRO, F., BASTOS, R., MARQUES, M. & COSTA SANTOS, C. (2008). Infliximab dose intensification by shortening infusion intervals. Inflamm Bowel Dis, 14 (3), 432-4.

MAGRO, F., MARQUES, M. & SANTOS, C. C. (2008). Episodic Infliximab Treatment Induces Infusion Reactions. Inflammatory Bowel Diseases, 14 (11), 1608-1610.

MAIA, J., ALMEIDA, L., FALCAO, A., SOARES, E., MOTA, F., POTGIETER, M. A., POTGIETER, J. H. & SOARES-DA-SILVA, P. (2008). Effect of renal impairment on the pharmacokinetics of eslicarbazepine acetate. Int J Clin Pharmacol Ther, 46 (3), 119-130.

MARQUES, M., MAGRO, F., CARDOSO, H., CARNEIRO, F., PORTUGAL, R., LOPES, J. & COSTA SANTOS, C. (2008). Infliximab-induced lupus-like syndrome associated with autoimmune hepatitis. Inflamm Bowel Dis, 14 (5), 723-5.

MORATO, M., SOUSA, T. & ALBINO-TEIXEIRA, A. (2008). Purinergic receptors in the splanchnic circulation. Purinergic Signal, 4 (3), 267-85.

NUNES, M. A., SANTOS, S., CORDEIRO, J. M., NEVES, P., SILVA, V. S., SYKES, A., MORGADO, F., DUNANT, Y. & GONCALVES, P. P. (2008). Acetylcholine release and choline uptake by cuttlefish (Sepia officinalis) optic lobe synaptosomes. Biol Bull, 214 (1), 1-5.

PASSARINHA, L. A., BONIFACIO, M. J., SOARES-DA-SILVA, P. & QUEIROZ, J. A. (2008). A new approach on the purification of recombinant human soluble catechol-O-methyltransferase from an Escherichia coli extract using hydrophobic interaction chromatography. J Chromatogr A, 1177 (2), 287-96.

PEDROSA, R., VILLAR, V. A., PASCUA, A. M., SIMAO, S., HOPFER, U., JOSE, P. A. & SOARES-DA-SILVA, P. (2008). H2O2 stimulation of the Cl-/HCO3- exchanger by angiotensin II and angiotensin II type 1 receptor distribution in membrane microdomains. Hypertension, 51 (5), 1332-8.

PEREIRA, M. L., CARVALHO, J. C., PERES, F., GUTIERRES, M. & FERNANDES, M. H. (2008). Behaviour of human osteoblastic cells cultured on plasma-sprayed titanium implants in the presence of nicotine. Clin Oral Implants Res, 19 (6), 582-9.

PINTO, V., PINHO, M. J., HOPFER, U., JOSE, P. A. & SOARES-DA-SILVA, P. (2008). Oxidative stress and the genomic regulation of aldosterone-stimulated NHE1 activity in SHR renal proximal tubular cells. Mol Cell Biochem, 310 (1-2), 191-201.

SALGUEIREDO, E., VILA, M., SILVA, M. A., LOPES, M. A., SANTOS, J. D., COSTA, F. M., SILVA, R. F., GOMES, P. S. & FEMANDES, M. H. (2008). Biocompatibility evaluation of DLC-coated Si3N4 substrates for biomedical applications. Diamond and Related Materials, 17 (4-5), 878-881.

SIMAO, S., FRAGA, S., JOSE, P. A. & SOARES-DA-SILVA, P. (2008). Oxidative stress plays a permissive role in alpha2-adrenoceptor-mediated events in immortalized SHR proximal tubular epithelial cells. Mol Cell Biochem, 315 (1-2), 31-9.

SIMAO, S., FRAGA, S., JOSE, P. A. & SOARES-DA-SILVA, P. (2008). Oxidative stress and alpha1-adrenoceptor-mediated stimulation of the Cl-/HCO3- exchanger in immortalized SHR proximal tubular epithelial cells. Br J Pharmacol, 153 (7), 1445-55.

SIMAO, S., PEDROSA, R., HOPFER, U., MOUNT, D. B., JOSE, P. A. & SOARES-DA-SILVA, P. (2008). Short-term regulation of the Cl-/HCO3(-) exchanger in immortalized SHR proximal tubular epithelial cells. Biochem Pharmacol, 75 (11), 2224-33.

SOUSA, T., PINHO, D., MORATO, M., MARQUES-LOPES, J., FERNANDES, E., AFONSO, J., OLIVEIRA, S., CARVALHO, F. & ALBINO-TEIXEIRA, A. (2008). Role of superoxide and hydrogen peroxide in hypertension induced by an antagonist of adenosine receptors. Eur J Pharmacol, 588 (2-3), 267-76.

TIMOTEO, M. A., OLIVEIRA, L., CAMPESATTO-MELLA, E., BARROSO, A., SILVA, C., MAGALHAES-CARDOSO, M. T., ALVES-DO-PRADO, W. & CORREIA-DE-SA, P. (2008). Tuning adenosine A1 and A2A receptors activation mediates L-citrulline-induced inhibition of [3H]-acetylcholine release depending on nerve stimulation pattern. Neurochem Int, 52 (4-5), 834-45.

VAZ-DA-SILVA, M., LOUREIRO, A. I., FALCAO, A., NUNES, T., ROCHA, J. F., FERNANDES-LOPES, C., SOARES, E., WRIGHT, L., ALMEIDA, L. & SOARES-DA-SILVA, P. (2008). Effect of food on the pharmacokinetic profile of trans-resveratrol. Int J Clin Pharmacol Ther, 46 (11), 564-70.

VAZ-DA-SILVA, M., LOUREIRO, A. I., NUNES, T., LOPES, C., ROCHA, J., MACHADO, R., COSTA, R., TORRAO, L., FALCAO, A., WRIGHT, L., ALMEIDA, L. & SOARES-DA-SILVA, P. (2008). Pharmacokinetic-pharmacodynamic interaction between nebicapone, a novel catechol-o-methyltransferase inhibitor, and controlled-release levodopa/carbidopa 200 mg/50 mg : randomized, double-blind, placebo-controlled, crossover study in healthy subjects. Drugs R D, 9 (6), 435-446.

ALMEIDA, L., VAZ-DA-SILVA, M., FALCAO, A., SOARES, E., COSTA, R., LOUREIRO, A. I., FERNANDES-LOPES, C., ROCHA, J. F., NUNES, T., WRIGHT, L. & SOARES-DA-SILVA, P. (2009). Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers. Mol Nutr Food Res, 53 Suppl 1 S7-15.

AMARAL, J. S., PINHO, M. J. & SOARES-DA-SILVA, P. (2009). Regulation of amino acid transporters in the rat remnant kidney. Nephrol Dial Transplant, 24 (7), 2058-67.

AMARAL, M., GOMES, P. S., LOPES, M. A., SANTOS, J. D., SILVA, R. F. & FERNANDES, M. H. (2009). Cytotoxicity evaluation of nanocrystalline diamond coatings by fibroblast cell cultures. Acta Biomater, 5 (2), 755-63.

BAETEN, D., VAN HAGEN, M., MAGRO, F., FILIPE, P. & FONSECA, J. E. (2009). Immune-mediated inflammatory diseases: a new multidisciplinary concept. Acta Reumatol Port, 34 (3), 457-9.

BANCILA, V., CORDEIRO, J. M., BLOC, A. & DUNANT, Y. (2009). Nicotine-induced and depolarisation-induced glutamate release from hippocampus mossy fibre synaptosomes: two distinct mechanisms. J Neurochem, 110 (2), 570-80.

BEETZ, N., HARRISON, M. D., BREDE, M., ZONG, X., URBANSKI, M. J., SIETMANN, A., KAUFLING, J., BARROT, M., SEELIGER, M. W., VIEIRA-COELHO, M. A., HAMET, P., GAUDET, D., SEDA, O., TREMBLAY, J., KOTCHEN, T. A., KALDUNSKI, M., NUSING, R., SZABO, B., JACOB, H. J., COWLEY, A. W., JR., BIEL, M., STOLL, M., LOHSE, M. J., BROECKEL, U. & HEIN, L. (2009). Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice. J Clin Invest, 119 (12), 3597-3612.

BONIFACIO, M. J., LOUREIRO, A. I., TORRAO, L., FERNANDES-LOPES, C., WRIGHT, L., PINHO, M. J. & SOARES-DA-SILVA, P. (2009). Species differences in pharmacokinetic and pharmacodynamic properties of nebicapone. Biochem Pharmacol, 78 (8), 1043-51.

CHARRUA, A., REGUENGA, C., CORDEIRO, J. M., CORREIADE-SA, P., PAULE, C., NAGY, I., CRUZ, F. & AVELINO, A. (2009). Functional transient receptor potential vanilloid 1 is expressed in human urothelial cells. J Urol, 182 (6), 2944-50.

COUTINHO, I., PEREIRA, G., SIMOES, M. F., CORTE-REAL, M., GONCALVES, J. & SARAIVA, L. (2009). Selective activation of protein kinase C-delta and -epsilon by 6,11,12,14-tetrahydroxy-abieta-5,8,11,13-tetraene-7-one (coleon U). Biochem Pharmacol, 78 (5), 449-59.

DUARTE-ARAUJO, M., NASCIMENTO, C., TIMOTEO, M. A., MAGALHAES-CARDOSO, M. T. & CORREIA-DE-SA, P. (2009). Relative contribution of ecto-ATPase and ecto-ATPDase pathways to the biphasic effect of ATP on acetylcholine release from myenteric motoneurons. Br J Pharmacol, 156 (3), 519-33.

DUNANT, Y., CORDEIRO, J. M. & GONCALVES, P. P. (2009). Exocytosis, mediatophore, and vesicular Ca2+/H+ antiport in rapid neurotransmission. Ann N Y Acad Sci, 1152 100-12.

ELGER, C., HALASZ, P., MAIA, J., ALMEIDA, L. & SOARES-DA-SILVA, P. (2009). Efficacy and safety of eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures: a randomized, double-blind, placebo-controlled, parallel-group phase III study. Epilepsia, 50 (3), 454-63.

FERNANDES, L. F., COSTA, M. A., FERNANDES, M. H. & TOMAS, H. (2009). Osteoblastic behavior of human bone marrow cells cultured over adsorbed collagen layer, over surface of collagen gels, and inside collagen gels. Connect Tissue Res, 50 (5), 336-46.

FONTES-SOUSA, A. P., MOURA, C., CARNEIRO, C. S., TEIXEIRA-PINTO, A., AREIAS, J. C. & LEITE-MOREIRA, A. F. (2009). Echocardiographic evaluation including tissue Doppler imaging in New Zealand white rabbits sedated with ketamine and midazolam. Vet J, 181 (3), 326-31.

FONTES-SOUSA, A. P., PIRES, A. L., CARNEIRO, C. S., BRAS-SILVA, C. & LEITE-MOREIRA, A. F. (2009). Effects of adrenomedullin on systolic and diastolic myocardial function. Peptides, 30 (4), 796-802.

FONTES-SOUSA, A. P., PIRES, A. L., MONTEIRO-CARDOSO, V. F. & LEITE-MOREIRA, A. F. (2009). Urotensin II-induced increase in myocardial distensibility is modulated by angiotensin II and endothelin-1. Physiol Res, 58 (5), 653-60.

GIL-NAGEL, A., LOPES-LIMA, J., ALMEIDA, L., MAIA, J. & SOARES-DA-SILVA, P. (2009). Efficacy and safety of 800 and 1200 mg eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures. Acta Neurol Scand, 120 (5), 281-7.

GOMES, P., SIMAO, S., SILVA, E., PINTO, V., AMARAL, J. S., AFONSO, J., SERRAO, M. P., PINHO, M. J. & SOARES-DA-SILVA, P. (2009). Aging increases oxidative stress and renal expression of oxidant and antioxidant enzymes that are associated with an increased trend in systolic blood pressure. Oxidative Medicine and Cellular Longevity, 2 (3), 138-145.

GONCALVES, P., ARAUJO, J. R., PINHO, M. J. & MARTEL, F. (2009). Modulation of butyrate transport in Caco-2 cells. Naunyn Schmiedebergs Arch Pharmacol, 379 (4), 325-36.

GUIMARAES, J., MATOS, E., ROSAS, M. J., VIEIRA-COELHO, A., BORGES, N., CORREIA, F., VAZ, R. & GARRETT, C. (2009). Modulation of nutritional state in Parkinsonian patients with bilateral subthalamic nucleus stimulation. J Neurol, 256 (12), 2072-8.

KEATING, E., GONCALVES, P., COSTA, F., CAMPOS, I., PINHO, M. J., AZEVEDO, I. & MARTEL, F. (2009). Comparison of the transport characteristics of bioactive substances in IUGR and normal placentas. Pediatr Res, 66 (5), 495-500.

LARANJEIRA, M. S., DIAS, A. G., SANTOS, J. D. & FERNANDES, M. H. (2009). In vitro biological characterization of macroporous 3D Bonelike (R) structures prepared through a 3D machining technique. Materials Science & Engineering C-Biomimetic and Supramolecular Systems, 29 (3), 930-935.

MAGRO, F., PORTELA, F., LAGO, P., RAMOS DE DEUS, J., VIEIRA, A., PEIXE, P., CREMERS, I., COTTER, J., CRAVO, M., TAVARES, L., REIS, J., GONCALVES, R., LOPES, H., CALDEIRA, P., MINISTRO, P., CARVALHO, L., AZEVEDO, L. & DA COSTA-PEREIRA, A. (2009). Crohn's disease in a southern European country: Montreal classification and clinical activity. Inflamm Bowel Dis, 15 (9), 1343-50.

MARQUES-LOPES, J., PINTO, M., PINHO, D., MORATO, M., PATINHA, D., ALBINO-TEIXEIRA, A. & TAVARES, I. (2009). Microinjection of angiotensin II in the caudal ventrolateral medulla induces hyperalgesia. Neuroscience, 158 (4), 1301-10.

MORAIS, P., MAGINA, S., RIBEIRO MDO, C., RODRIGUES, M., LOPES, J. M., THANH HLE, T., WEHNERT, M. & GUIMARAES, H. (2009). Restrictive dermopathy--a lethal congenital laminopathy. Case report and review of the literature. Eur J Pediatr, 168 (8), 1007-12.

MOREIRA-RODRIGUES, M., SAMPAIO-MAIA, B. & PESTANA, M. (2009). Renal dopaminergic system activity in rat remnant kidney up to twenty-six weeks after surgery. Life Sci, 84 (13-14), 409-14.

NOGUEIRA, A., DUARTE, A. F., MAGINA, S. & AZEVEDO, F. (2009). Pellagra associated with esophageal carcinoma and alcoholism. Dermatol Online J, 15 (5), 8.

NOGUEIRA, A., DUARTE, A. F., MORAIS, P., MAGINA, S. & AZEVEDO, F. (2009). Whitish bullae on the fingers: what is the diagnosis? Tophaceous gout. Dermatol Online J, 15 (6), 9.

NUNES, T., ALMEIDA, L., ROCHA, J. F., FALCAO, A., FERNANDES-LOPES, C., LOUREIRO, A. I., WRIGHT, L., VAZ-DA-SILVA, M. & SOARES-DA-SILVA, P. (2009). Pharmacokinetics of trans-resveratrol following repeated administration in healthy elderly and young subjects. J Clin Pharmacol, 49 (12), 1477-82.

NUNES, T., MACHADO, R., ROCHA, J. F., FERNANDES-LOPES, C., COSTA, R., TORRAO, L., LOUREIRO, A. I., FALCAO, A., VAZ-DA-SILVA, M., WRIGHT, L., ALMEIDA, L. & SOARES-DA-SILVA, P. (2009). Pharmacokinetic-pharmacodynamic interaction between nebicapone and controlled-release levodopa/benserazide: a single-center, Phase I, double-blind, randomized, placebo-controlled, four-way crossover study in healthy subjects. Clin Ther, 31 (10), 2258-71.

OLIVEIRA, J. M. & GONCALVES, J. (2009). In situ mitochondrial Ca2+ buffering differences of intact neurons and astrocytes from cortex and striatum. J Biol Chem, 284 (8), 5010-20.

OLIVEIRA, L., TIMOTEO, M. A. & CORREIA-DE-SA, P. (2009). Negative crosstalk between M1 and M2 muscarinic autoreceptors involves endogenous adenosine activating A1 receptors at the rat motor endplate. Neurosci Lett, 459 (3), 127-31.

PEREIRA, M. L., CARVALHO, J. C., PERES, F. & FERNANDES, M. H. (2009). Effect of nicotine in matrix mineralization by human bone marrow and Saos-2 cells cultured on the surface of plasma-sprayed titanium implants. J Biomed Mater Res A, 88 (1), 84-93.

PIMENTEL-NUNES, P., DINIS-RIBEIRO, M. & MAGRO, F. (2009). Systematic review on drug and diet-induced endoscopic remission in Crohn's disease. Eur J Gastroenterol Hepatol, 21 (5), 491-503.

PINHO, M. J., AMARAL, J., PINTO, V., SERRÃO, M. P. & SOARES-DA-SILVA, P. (2009). Regulation of renal LAT2 and 4F2hc expression by aldosterone. Journal of Epithelial Biology and Pharmacology, 2 36-43.

QUINTAS, C., FRAGA, S., GONCALVES, J. & QUEIROZ, G. (2009). The P2Y(1) and P2Y(12) receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues. Neurochem Int, 55 (7), 505-13.

ROCHA, J. F., VAZ-DA-SILVA, M., ALMEIDA, L., FALCAO, A., NUNES, T., SANTOS, A. T., MARTINS, F., FONTES-RIBEIRO, C., MACEDO, T. & SOARES-DA-SILVA, P. (2009). Effect of eslicarbazepine acetate on the pharmacokinetics of metformin in healthy subjects. Int J Clin Pharmacol Ther, 47 (4), 255-61.

SANTOS-ARAUJO, C., RONCON-ALBUQUERQUE, R., JR., MOREIRA-RODRIGUES, M., HENRIQUES-COELHO, T., QUELHAS-SANTOS, J., FARIA, B., SAMPAIO-MAIA, B., LEITE-MOREIRA, A. F. & PESTANA, M. (2009). Local modulation of the natriuretic peptide system in the rat remnant kidney. Nephrol Dial Transplant, 24 (6), 1774-82.

SHIROSAKI, Y., TSURU, K., HAYAKAWA, S., OSAKA, A., LOPES, M. A., SANTOS, J. D., COSTA, M. A. & FERNANDES, M. H. (2009). Physical, chemical and in vitro biological profile of chitosan hybrid membrane as a function of organosiloxane concentration. Acta Biomater, 5 (1), 346-55.

SILVA, E. & SOARES-DA-SILVA, P. (2009). Protein cytoskeleton and overexpression of Na(+),K(+)-ATPase in opossum kidney cells. J Cell Physiol, 221 (2), 318-24.

SILVA MARQUES, J. M., GOMES, P. S., SILVA, M. A., SILVERIO CABRITA, A. M., SANTOS, J. D. & FERNANDES, M. H. (2009). Growth and phenotypic expression of human endothelial cells cultured on a glass-reinforced hydroxyapatite. J Mater Sci Mater Med, 20 (3), 725-31.

SOORAJ HUSSAIN, N. P., GOMES, S., FERNANDES, M. H., LOPES, M. A. & SANTOS, J. D. (2009). Assessment of the osteoblastic cell response to a zinc glass reinforced hydroxyapatite composite (Zn-GRHA). Int. J. of Nano and Biomaterials, 2 (1/2/3/4/5), 100-9.

TITEUX, M., MENDONCA, V., DECHA, A., MOREIRA, E., MAGINA, S., MAIA, A., LACAZE-BUZY, L., MEJIA, J. E., TORRAO, L., CARVALHO, F., ECA-GUIMARAES, J. & HOVNANIAN, A. (2009). Keratitis-ichthyosis-deafness syndrome caused by GJB2 maternal mosaicism. J Invest Dermatol, 129 (3), 776-9.

VAZ DA SILVA, M., COSTA, R., SOARES, E., MAIA, J., FALCAO, A., ALMEIDA, L. & SOARES DA SILVA, P. (2009). Effect of eslicarbazepine acetate on the pharmacokinetics of digoxin in healthy subjects. Fundam Clin Pharmacol, 23 (4), 509-14.

VIEIRA, C., DUARTE-ARAUJO, M., ADAES, S., MAGALHAES-CARDOSO, T. & CORREIA-DE-SA, P. (2009). Muscarinic M(3) facilitation of acetylcholine release from rat myenteric neurons depends on adenosine outflow leading to activation of excitatory A(2A) receptors. Neurogastroenterol Motil, 21 (10), 1118-e95.

VIEIRA-COELHO, M. A., SERRAO, M. P., AFONSO, J., PINTO, C. E. & MOURA, E. (2009). Catecholamine synthesis and metabolism in the central nervous system of mice lacking alpha-adrenoceptor subtypes. Br J Pharmacol, 158 (3), 726-37.

ALMEIDA, L., LOUREIRO, A. I., VAZ-DA-SILVA, M., TORRAO, L., MAIA, J., FERNANDES-LOPES, C., FALCAO, A., IGREJA, B., WRIGHT, L. & SOARES-DA-SILVA, P. (2010). Chronopharmacology of nebicapone, a new catechol-O-methyltransferase inhibitor. Curr Med Res Opin, 26 (5), 1097-108.

ALMEIDA, L., NUNES, T., SICARD, E., ROCHA, J. F., FALCAO, A., BRUNET, J. S., LEFEBVRE, M. & SOARES-DA-SILVA, P. (2010). Pharmacokinetic interaction study between eslicarbazepine acetate and lamotrigine in healthy subjects. Acta Neurol Scand, 121 (4), 257-64.

ALVES, G., FORTUNA, A., SOUSA, J., DIREITO, R., ALMEIDA, A., ROCHA, M., FALCAO, A. & SOARES-DA-SILVA, P. (2010). Enantioselective assay for therapeutic drug monitoring of eslicarbazepine acetate: no interference with carbamazepine and its metabolites. Ther Drug Monit, 32 (4), 512-6.

AZEVEDO, E., SANTOS, R., FREITAS, J., ROSAS, M. J., GAGO, M., GARRETT, C. & ROSENGARTEN, B. (2010). Deep brain stimulation does not change neurovascular coupling in non-motor visual cortex: an autonomic and visual evoked blood flow velocity response study. Parkinsonism Relat Disord, 16 (9), 600-3.

AZEVEDO, L. F., MAGRO, F., PORTELA, F., LAGO, P., DEUS, J., COTTER, J., CREMERS, I., VIEIRA, A., PEIXE, P., CALDEIRA, P., LOPES, H., GONCALVES, R., REIS, J., CRAVO, M., BARROS, L., MINISTRO, P., LURDES, M., DUARTE, A., CAMPOS, M., CARVALHO, L. & COSTA-PEREIRA, A. (2010). Estimating the prevalence of inflammatory bowel disease in Portugal using a pharmaco-epidemiological approach. Pharmacoepidemiol Drug Saf, 19 (5), 499-510.

BARREIRO-DE ACOSTA, M., MAGRO, F., CARPIO, D., LAGO, P., ECHARRI, A., COTTER, J., PEREIRA, S., GONCALVES, R., LORENZO, A., CARVALHO, L., CASTRO, J., BARROS, L., DIAS, J. A., RODRIGUES, S., PORTELA, F., DIAS, C. & DA COSTA-PEREIRA, A. (2010). Ulcerative colitis in northern Portugal and Galicia in Spain. Inflamm Bowel Dis, 16 (7), 1227-38.

BEN-MENACHEM, E., GABBAI, A. A., HUFNAGEL, A., MAIA, J., ALMEIDA, L. & SOARES-DA-SILVA, P. (2010). Eslicarbazepine acetate as adjunctive therapy in adult patients with partial epilepsy. Epilepsy Res, 89 (2-3), 278-85.

COENTRAO, L., NEVES, A. & MOURA, D. (2010). Hydroxocobalamin treatment of acute cyanide poisoning with a jewellery-cleaning solution. BMJ Case Rep, 2010

COSTA-RODRIGUES, J., TEIXEIRA, C. A., SAMPAIO, P. & FERNANDES, M. H. (2010). Characterisation of the osteoclastogenic potential of human osteoblastic and fibroblastic conditioned media. J Cell Biochem, 109 (1), 205-16.

DE MATOS SILVA, L. F., DE PAULA RAMOS, E. R., AMBIEL, C. R., CORREIA-DE-SA, P. & ALVES-DO-PRADO, W. (2010). Apamin reduces neuromuscular transmission by activating inhibitory muscarinic M(2) receptors on motor nerve terminals. Eur J Pharmacol, 626 (2-3), 239-43.

FERREIRA, J. J., RASCOL, O., POEWE, W., SAMPAIO, C., ROCHA, J. F., NUNES, T., ALMEIDA, L. & SOARES-DA-SILVA, P. (2010). A Double-Blind, Randomized, Placebo and Active-Controlled Study of Nebicapone for the Treatment of Motor Fluctuations in Parkinson's Disease. CNS Neurosci Ther, 16 337-347.

FORTUNA, A., ALVES, G., FALCAO, A. & SOARES-DA-SILVA, P. (2010). Binding of licarbazepine enantiomers to mouse and human plasma proteins. Biopharm Drug Dispos, 31 (5-6), 362-6.

FORTUNA, A., SOUSA, J., ALVES, G., FALCAO, A. & SOARES-DA-SILVA, P. (2010). Development and validation of an HPLC-UV method for the simultaneous quantification of carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main metabolites in human plasma. Anal Bioanal Chem, 397 (4), 1605-15.

FRESCO, P., BORGES, F., MARQUES, M. P. & DINIZ, C. (2010). The anticancer properties of dietary polyphenols and its relation with apoptosis. Curr Pharm Des, 16 (1), 114-34.

GOMES PDE, S. & FERNANDES, M. H. (2010). Defensins in the oral cavity: distribution and biological role. J Oral Pathol Med, 39 (1), 1-9.

GOMES, P. S., BOTELHO, C., LOPES, M. A., SANTOS, J. D. & FERNANDES, M. H. (2010). Evaluation of human osteoblastic cell response to plasma-sprayed silicon-substituted hydroxyapatite coatings over titanium substrates. J Biomed Mater Res B Appl Biomater, 94 (2), 337-46.

GUIMARAES, J., VIEIRA-COELHO, A., ROSAS, M. J., MOURA, E., VAZ, R. & GARRETT, C. (2010). Acute renal failure in patients with bilateral deep brain stimulation. Mov Disord, 25 (14), 2462-4.

HALASZ, P., CRAMER, J. A., HODOBA, D., CZLONKOWSKA, A., GUEKHT, A., MAIA, J., ELGER, C., ALMEIDA, L. & SOARES-DA-SILVA, P. (2010). Long-term efficacy and safety of eslicarbazepine acetate: results of a 1-year open-label extension study in partial-onset seizures in adults with epilepsy. Epilepsia, 51 (10), 1963-9.

JOSE, P. A., SOARES-DA-SILVA, P., EISNER, G. M. & FELDER, R. A. (2010). Dopamine and G protein-coupled receptor kinase 4 in the kidney: role in blood pressure regulation. Biochim Biophys Acta, 1802 (12), 1259-67.

KISS, L. E., FERREIRA, H. S., TORRAO, L., BONIFACIO, M. J., PALMA, P. N., SOARES-DA-SILVA, P. & LEARMONTH, D. A. (2010). Discovery of a long-acting, peripherally selective inhibitor of catechol-O-methyltransferase. J Med Chem, 53 (8), 3396-411.

LARANJEIRA, M. S., FERNANDES, M. H. & MONTEIRO, F. J. (2010). Innovative macroporous granules of nanostructured-hydroxyapatite agglomerates: bioactivity and osteoblast-like cell behaviour. J Biomed Mater Res A, 95 (3), 891-900.

LEARMONTH, D. A., KISS, L. E. & SOARES-DA-SILVA, P. (2010). The chemistry of catechol-O-methyltransferase inhibitors. Int Rev Neurobiol, 95 119-62.

MAGRO, F. (2010). Management of inflammatory bowel disease with infliximab and other anti-tumor necrosis factor therapies: review of literature and case reports. Foreword. BioDrugs, 24 Suppl 1 1-2.

MAGRO, F., BARREIRO-DE ACOSTA, M., LAGO, P., CARPIO, D., COTTER, J., ECHARRI, A., GONCALVES, R., PEREIRA, S., CARVALHO, L., LORENZO, A., BARROS, L., CASTRO, J., DIAS, J. A., RODRIGUES, S., PORTELA, F., DIAS, C. & DA COSTA-PEREIRA, A. (2010). Clinical practice in Crohn's disease in bordering regions of two countries: different medical options, distinct surgical events. J Crohns Colitis, 4 (3), 301-11.

MAGRO, F. & PORTELA, F. (2010). Management of inflammatory bowel disease with infliximab and other anti-tumor necrosis factor alpha therapies. BioDrugs, 24 Suppl 1 3-14.

MARQUES, M., RODRIGUES, S., MARIZ, E., PINTO, J., VIDEIRA, T., BRITO, J., REIS, C., SIMOES-VENTURA, F. & MAGRO, F. (2010). Severe gram positive bacterial infection in an ulcerative colitis patient treated with Infliximab. J Crohns Colitis, 4 (1), 110-3.

MARQUES-LOPES, J., PINHO, D., ALBINO-TEIXEIRA, A. & TAVARES, I. (2010). The hyperalgesic effects induced by the injection of angiotensin II into the caudal ventrolateral medulla are mediated by the pontine A(5) noradrenergic cell group. Brain Res,

MILOVAN, D., ALMEIDA, L., ROMACH, M. K., NUNES, T., ROCHA, J. F., SOKOWLOSKA, M., SELLERS, E. M. & SOARES-DA-SILVA, P. (2010). Effect of eslicarbazepine acetate and oxcarbazepine on cognition and psychomotor function in healthy volunteers. Epilepsy Behav, 18 (4), 366-73.

MORAIS, P., PERALTA, L., MAGINA, S., BETTENCOURT, H. & AZEVEDO, F. (2010). Annular lesions on the lower limbs of young female. Dermatol Online J, 16 (7), 16.

MOREIRA-RODRIGUES, M., HENRIQUES-COELHO, T., MOURA, C., VASQUES-NOVOA, F., SAMPAIO-MAIA, B., PESTANA, M. & LEITE-MOREIRA, A. F. (2010). Cardiac dysfunction in HgCl2-induced nephrotic syndrome. Exp Biol Med (Maywood), 235 (3), 392-400.

MOREIRA-RODRIGUES, M., QUELHAS-SANTOS, J., SERRAO, P., FERNANDES-CERQUEIRA, C., SAMPAIO-MAIA, B. & PESTANA, M. (2010). Glycaemic control with insulin prevents the reduced renal dopamine D1 receptor expression and function in streptozotocin-induced diabetes. Nephrol Dial Transplant, 25 (9), 2945-53.

NOGUEIRA, A., DUARTE, A. F., MAGINA, S., CANELHAS, A., RESENDE, C. & AZEVEDO, F. (2010). Ofuji's disease - A diagnosis to consider in white patients. Eur J Dermatol, 20 (1), 124-5.

NUNES, T., ROCHA, J. F., VAZ-DA-SILVA, M., IGREJA, B., WRIGHT, L. C., FALCAO, A., ALMEIDA, L. & SOARES-DA-SILVA, P. (2010). Safety, Tolerability, and Pharmacokinetics of Etamicastat, a Novel Dopamine-beta-Hydroxylase Inhibitor, in a Rising Multiple-Dose Study in Young Healthy Subjects. Drugs R D, 10 (4), 225-42.

NUNES, T., SICARD, E., ALMEIDA, L., FALCAO, A., ROCHA, J. F., BRUNET, J. S., LEFEBVRE, M. & SOARES-DA-SILVA, P. (2010). Pharmacokinetic interaction study between eslicarbazepine acetate and topiramate in healthy subjects. Curr Med Res Opin, 26 (6), 1355-62.

OSORIO, F., MAGINA, S., CARVALHO, T., GONCALVES, M. H. & AZEVEDO, F. (2010). Mycobacterium marinum skin infection with tenosynovitis successfully treated with doxycycline. Dermatol Online J, 16 (9), 7.

OSORIO, F., MAGINA, S., NOGUEIRA, A. & AZEVEDO, F. (2010). Incontinentia Pigmenti with vesicular stage in utero. Dermatol Online J, 16 (10), 13.

PELAEZ-VARGAS, A., GALLEGO-PEREZ, D., FERRELL, N., FERNANDES, M. H., HANSFORD, D. & MONTEIRO, F. J. (2010). Early spreading and propagation of human bone marrow stem cells on isotropic and anisotropic topographies of silica thin films produced via microstamping. Microsc Microanal, 16 (6), 670-6.

PEREIRA, D. & GARRETT, C. (2010). [Risk factors for Parkinson disease: an epidemiologic study]. Acta Med Port, 23 (1), 15-24.

PEREIRA, M. L., CARVALHO, J. C., PERES, F. & FERNANDES, M. H. (2010). Simultaneous effects of nicotine, acrolein, and acetaldehyde on osteogenic-induced bone marrow cells cultured on plasma-sprayed titanium implants. Int J Oral Maxillofac Implants, 25 (1), 112-22.

PINTO, C. E., MOURA, E., SERRAO, M. P., MARTINS, M. J. & VIEIRA-COELHO, M. A. (2010). Effect of (-)-Delta(9)-tetrahydrocannabinoid on the hepatic redox state of mice. Braz J Med Biol Res, 43 (4), 325-9.

PINTO, V., PINHO, M. J., JOSE, P. A. & SOARES-DA-SILVA, P. (2010). Role of H(2)O(2) on the kinetics of low-affinity high-capacity Na(+)-dependent alanine transport in SHR proximal tubular epithelial cells. Biochem Biophys Res Commun, 398 (3), 553-8.

PORTELA, A., VASCONCELOS, M., BRANCO, R., GARTNER, F., FARIA, M. & CAVALHEIRO, J. (2010). An in vitro and in vivo investigation of the biological behavior of a ferrimagnetic cement for highly focalized thermotherapy. J Mater Sci Mater Med, 21 (8), 2413-23.

PORTELA, F., MAGRO, F., LAGO, P., COTTER, J., CREMERS, I., DE DEUS, J., VIEIRA, A., LOPES, H., CALDEIRA, P., BARROS, L., REIS, J., CARVALHO, L., GONCALVES, R., CAMPOS, M. J., MINISTRO, P., DUARTE, M. A., AMIL, J., RODRIGUES, S., AZEVEDO, L. & COSTA-PEREIRA, A. (2010). Ulcerative colitis in a Southern European country: a national perspective. Inflamm Bowel Dis, 16 (5), 822-9.

RODRIGUES, A. M., ROSAS, M. J., GAGO, M. F., SOUSA, C., FONSECA, R., LINHARES, P., BASTO, M. A., SOUSA, G., GARRETT, C. & VAZ, R. (2010). Suicide attempts after subthalamic nucleus stimulation for Parkinson's disease. Eur Neurol, 63 (3), 176-9.

RODRIGUES, S., MAGRO, F., SOARES, J., NUNES, A. C., LOPES, S., MARQUES, M., RIO, E. & MACEDO, G. (2010). Case series: ulcerative colitis, multiple sclerosis, and interferon-beta 1a. Inflamm Bowel Dis, 16 (12), 2001-3.

SILVA, E., PINTO, V., SIMAO, S., SERRAO, M. P., AFONSO, J., AMARAL, J., PINHO, M. J., GOMES, P. & SOARES-DA-SILVA, P. (2010). Renal aging in WKY rats: changes in Na+,K+ -ATPase function and oxidative stress. Exp Gerontol, 45 (12), 977-83.

SILVA, E. & SOARES-DA-SILVA, P. (2010). Long-term regulation of Na(+),K(+)-ATPase in Opossum Kidney Cells by ouabain. J Cell Physiol,

SILVA, M. A., GOMES, P. S., VILA, M., LOPES, M. A., SANTOS, J. D., SILVA, R. F. & FERNANDES, M. H. (2010). New titanium and titanium/hydroxyapatite coatings on ultra-high-molecular-weight polyethylene-in vitro osteoblastic performance. Biomed Mater, 5 (3), 035014.

SIMAO, S., GOMES, P., JOSE, P. A. & SOARES-DA-SILVA, P. (2010). Increased responsiveness to JNK1/2 mediates the enhanced H2O2-induced stimulation of Cl-/HCO3- exchanger activity in immortalized renal proximal tubular epithelial cells from the SHR. Biochem Pharmacol, 80 (6), 913-9.

TEIXEIRA, S., FERNANDES, M. H., FERRAZ, M. P. & MONTEIRO, F. J. (2010). Proliferation and mineralization of bone marrow cells cultured on macroporous hydroxyapatite scaffolds functionalized with collagen type I for bone tissue regeneration. J Biomed Mater Res A, 95 (1), 1-8.

VAZ-DA-SILVA, M., ALMEIDA, L., FALCAO, A., SOARES, E., MAIA, J., NUNES, T. & SOARES-DA-SILVA, P. (2010). Effect of eslicarbazepine acetate on the steady-state pharmacokinetics and pharmacodynamics of warfarin in healthy subjects during a three-stage, open-label, multiple-dose, single-period study. Clin Ther, 32 (1), 179-92.

WRIGHT, L. C., MAIA, J., LOUREIRO, A. I., ALMEIDA, L. & SOARES-DA-SILVA, P. (2010). Pharmacokinetics, disposition, and metabolism of [14C]-nebicapone in humans. Drug Metab Lett, 4 (3), 149-62.

ALBUQUERQUE, A., MAGRO, F., RODRIGUES, S., LOPES, J., LOPES, S., DIAS, J. M., CARNEIRO, F. & MACEDO, G. (2011). Metastatic cutaneous Crohn's disease of the face: a case report and review of the literature. Eur J Gastroenterol Hepatol, 23 (10), 954-6.

ALBUQUERQUE, A., MAGRO, F., RODRIGUES, S., LOPES, S., PEREIRA, P., MELO, R. B., MADUREIRA, M. & MACEDO, G. (2011). Liver abscess of the caudate lobe due to Staphylococcus aureus in an ulcerative colitis patient: First case report. J Crohns Colitis, 5 (4), 360-3.

BORNIA, E. C., CORREIA-DE-SA, P. & ALVES-DO-PRADO, W. (2011). Presynaptic facilitatory A(2A) receptors mediate fade induced by neuromuscular relaxants that exhibit anticholinesterase activity. Clin Exp Pharmacol Physiol,

BURISCH, J., CUKOVIC-CAVKA, S., KAIMAKLIOTIS, I., SHONOVA, O., ANDERSEN, V., DAHLERUP, J. F., ELKJAER, M., LANGHOLZ, E., PEDERSEN, N., SALUPERE, R., KOLHO, K. L., MANNINEN, P., LAKATOS, P. L., SHUHAIBAR, M., ODES, S., MARTINATO, M., MIHU, I., MAGRO, F., BELOUSOVA, E., FERNANDEZ, A., ALMER, S., HALFVARSON, J., HART, A. & MUNKHOLM, P. (2011). Construction and validation of a web-based epidemiological database for inflammatory bowel diseases in Europe An EpiCom study. J Crohns Colitis, 5 (4), 342-9.

CAMPOS, N., MAGRO, F., CASTRO, A. R., CABRAL, J., RODRIGUES, P., SILVA, R., APPELBERG, R., RODRIGUES, S., LOPES, S., MACEDO, G. & SARMENTO, A. (2011). Macrophages from IBD patients exhibit defective tumour necrosis factor-alpha secretion but otherwise normal or augmented pro-inflammatory responses to infection. Immunobiology, 216 (8), 961-70.

CARVALHO, L., ALBERTO, N. J., GOMES, P. S., NOGUEIRA, R. N., PINTO, J. L. & FERNANDES, M. H. (2011). In the trail of a new bio-sensor for measuring strain in bone: osteoblastic biocompatibility. Biosens Bioelectron, 26 (10), 4046-52.

CASTANHEIRA, L., FRESCO, P. & MACEDO, A. F. (2011). Guidelines for the management of chronic medication in the perioperative period: systematic review and formal consensus. J Clin Pharm Ther, 36 (4), 446-67.

COENTRAO, L. & MOURA, D. (2011). Acute cyanide poisoning among jewelry and textile industry workers. Am J Emerg Med, 29 (1), 78-81.

CORDEIRO, J., GONCALVES, P. P. & DUNANT, Y. (2011). Synaptic vesicles control the time course of neurotransmitter secretion via a Ca(2)+/H+ antiport. J Physiol, 589 (Pt 1), 149-67.

CORTEZ, P. P., ATAYDE, L. M., SILVA, M. A., ARMADA-DA-SILVA, P., FERNANDES, M. H., AFONSO, A., LOPES, M. A., MAURICIO, A. C. & SANTOS, J. D. (2011). Characterization and preliminary in vivo evaluation of a novel modified hydroxyapatite produced by extrusion and spheronization techniques. J Biomed Mater Res B Appl Biomater, 99 (1), 170-9.

COSTA, M. A., BARBOSA, A., NETO, E., SA-E-SOUSA, A., FREITAS, R., NEVES, J. M., MAGALHAES-CARDOSO, T., FERREIRINHA, F. & CORREIA-DE-SA, P. (2011). On the role of subtype selective adenosine receptor agonists during proliferation and osteogenic differentiation of human primary bone marrow stromal cells. J Cell Physiol, 226 (5), 1353-66.

COSTA-RODRIGUES, J., FERNANDES, A. & FERNANDES, M. H. (2011). Spontaneous and induced osteoclastogenic behaviour of human peripheral blood mononuclear cells and their CD14(+) and CD14(-) cell fractions. Cell Prolif, 44 (5), 410-9.

COSTA-RODRIGUES, J., FERNANDES, A. & FERNANDES, M. H. (2011). Reciprocal osteoblastic and osteoclastic modulation in co-cultured MG63 osteosarcoma cells and human osteoclast precursors. J Cell Biochem, 112 (12), 3704-13.

COSTA-RODRIGUES, J. & FERNANDES, M. H. (2011). Paracrine-mediated differentiation and activation of human haematopoietic osteoclast precursor cells by skin and gingival fibroblasts. Cell Prolif, 44 (3), 264-73.

COSTA-RODRIGUES, J., TEIXEIRA, C. A. & FERNANDES, M. H. (2011). Paracrine-mediated osteoclastogenesis by the osteosarcoma MG63 cell line: is RANKL/RANK signalling really important? Clin Exp Metastasis, 28 (6), 505-14.

DA COSTA, A. G., GAGO, M. F. & GARRETT, C. (2011). [Cerebrospinal fluid biomarkers for the early diagnosis of Parkinson's disease]. Acta Med Port, 24 Suppl 4 761-8.

DE GOMES, P. S., FIGUEIRAL, M. H., FERNANDES, M. H. & SCULLY, C. (2011). Cytotoxicity of denture adhesives. Clin Oral Investig, 15 (6), 885-93.

FALCAO-PIRES, I., FONTES-SOUSA, A. P., LOPES-CONCEICAO, L., BRAS-SILVA, C. & LEITE-MOREIRA, A. F. (2011). Modulation of myocardial stiffness by beta-adrenergic stimulation--its role in normal and failing heart. Physiol Res, 60 (4), 599-609.

FORTUNA, A., BICKER, J., ALVES, G., FALCAO, A. & SOARES-DA-SILVA, P. (2011). A chiral HPLC-UV method for the quantification of dibenz[b,f]azepine-5-carboxamide derivatives in mouse plasma and brain tissue: eslicarbazepine acetate, carbamazepine and main metabolites. J Sep Sci, 34 (12), 1391-401.

GOMES, P. S. & FERNANDES, M. H. (2011). Rodent models in bone-related research: the relevance of calvarial defects in the assessment of bone regeneration strategies. Lab Anim, 45 (1), 14-24.

GONCALVES, P., ARAUJO, J. R., PINHO, M. J. & MARTEL, F. (2011). In vitro studies on the inhibition of colon cancer by butyrate and polyphenolic compounds. Nutr Cancer, 63 (2), 282-94.

KOZMUS, C. E., MOURA, E., SERRAO, M. P., REAL, H., GUIMARAES, J. T., GUEDES-DE-PINHO, P., DUARTE, B. P., MARQUES, F., MARTINS, M. J. & VIEIRA-COELHO, M. A. (2011). Influence of dietary supplementation with dextrin or oligofructose on the hepatic redox balance in rats. Mol Nutr Food Res, 55 (11), 1735-9.

LOPES, P. P., FERREIRA, B. J., GOMES, P. S., CORREIA, R. N., FERNANDES, M. H. & FERNANDES, M. H. (2011). Silicate and borate glasses as composite fillers: a bioactivity and biocompatibility study. J Mater Sci Mater Med, 22 (6), 1501-10.

LOPES, V. R., SCHMIDTKE, M., HELENA FERNANDES, M., MARTINS, R. & VASCONCELOS, V. (2011). Cytotoxicity in L929 fibroblasts and inhibition of herpes simplex virus type 1 Kupka by estuarine cyanobacteria extracts. Toxicol In Vitro, 25 (4), 944-50.

LOUREIRO, A. I., FERNANDES-LOPES, C., BONIFACIO, M. J., WRIGHT, L. C. & SOARES-DA-SILVA, P. (2011). Hepatic UDP-glucuronosyltransferase is responsible for eslicarbazepine glucuronidation. Drug Metab Dispos, 39 (9), 1486-94.

LOUREIRO, A. I., FERNANDES-LOPES, C., WRIGHT, L. C. & SOARES-DA-SILVA, P. (2011). Development and validation of an enantioselective liquid-chromatography/tandem mass spectrometry method for the separation and quantification of eslicarbazepine acetate, eslicarbazepine, R-licarbazepine and oxcarbazepine in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci, 879 (25), 2611-8.

MACHADO, E., FERNANDES, M. H. & GOMES, P. D. (2011). Dental stem cells for craniofacial tissue engineering. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 728-733.

MAGINA, S., ESTEVES-PINTO, C., MOURA, E., SERRAO, M. P., MOURA, D., PETROSINO, S., DI MARZO, V. & VIEIRA-COELHO, M. A. (2011). Inhibition of basal and ultraviolet B-induced melanogenesis by cannabinoid CB(1) receptors: a keratinocyte-dependent effect. Arch Dermatol Res, 303 (3), 201-10.

MAGRO, F., LOPES, S., RODRIGUES, S. & AZEVEDO, I. (2011). How to manage pouchitis in ulcerative colitis? Curr Drug Targets, 12 (10), 1454-61.

MORAIS, P., MAGINA, S., MATEUS, M., TRINDADE, E., JESUS, J. M. & AZEVEDO, F. (2011). Efficacy and safety of propranolol in the treatment of parotid hemangioma. Cutan Ocul Toxicol, 30 (3), 245-8.

MOURA, E., PINTO, C. E., CALO, A., SERRAO, M. P., AFONSO, J. & VIEIRA-COELHO, M. A. (2011). alpha(2)-Adrenoceptor-mediated inhibition of catecholamine release from the adrenal medulla of spontaneously hypertensive rats is preserved in the early stages of hypertension. Basic Clin Pharmacol Toxicol, 109 (4), 253-60.

MUNZ, M. R., FARIA, M. A., MONTEIRO, J. R., AGUAS, A. P. & AMORIM, M. J. (2011). Surgical porcine myocardial infarction model through permanent coronary occlusion. Comp Med, 61 (5), 445-52.

NOGUEIRA, A., CRUZ, M. J., MAGINA, S. & AZEVEDO, F. (2011). Pink papules on the dorsum of the finger. Int J Dermatol, 50 (11), 1334-5.

NORONHA-MATOS, J. B., MORAIS, T., TRIGO, D., TIMOTEO, M. A., MAGALHAES-CARDOSO, M. T., OLIVEIRA, L. & CORREIA-DE-SA, P. (2011). Tetanic failure due to decreased endogenous adenosine A(2A) tonus operating neuronal Ca(v) 1 (L-type) influx in Myasthenia gravis. J Neurochem, 117 (5), 797-811.

NUNES, T., ROCHA, J. F., VAZ-DA-SILVA, M., FALCAO, A., ALMEIDA, L. & SOARES-DA-SILVA, P. (2011). Pharmacokinetics and tolerability of etamicastat following single and repeated administration in elderly versus young healthy male subjects: an open-label, single-center, parallel-group study. Clin Ther, 33 (6), 776-91.

PELAEZ-VARGAS, A., GALLEGO-PEREZ, D., MAGALLANES-PERDOMO, M., FERNANDES, M. H., HANSFORD, D. J., DE AZA, A. H., PENA, P. & MONTEIRO, F. J. (2011). Isotropic micropatterned silica coatings on zirconia induce guided cell growth for dental implants. Dent Mater, 27 (6), 581-9.

PEREIRA, M., BORNIA, E., CORREIA-DE-SA, P. & ALVES-DO-PRADO, W. (2011). Presynaptic muscarinic and adenosine receptors are involved in 2 Hz-induced train-of-four fade caused by antinicotinic neuromuscular relaxants in the rat. Clin Exp Pharmacol Physiol, 38 (11), 764-70.

PERUCCA, E., ELGER, C., HALASZ, P., FALCAO, A., ALMEIDA, L. & SOARES-DA-SILVA, P. (2011). Pharmacokinetics of eslicarbazepine acetate at steady-state in adults with partial-onset seizures. Epilepsy Res, 96 (1-2), 132-9.

PEYRIN-BIROULET, L., FERRANTE, M., MAGRO, F., CAMPBELL, S., FRANCHIMONT, D., FIDDER, H., STRID, H., ARDIZZONE, S., VEEREMAN-WAUTERS, G., CHEVAUX, J. B., ALLEZ, M., DANESE, S., STURM, A., SCIENTIFIC COMMITTEE OF THE EUROPEAN, C. S. & COLITIS, O. (2011). Results from the 2nd Scientific Workshop of the ECCO. I: Impact of mucosal healing on the course of inflammatory bowel disease. J Crohns Colitis, 5 (5), 477-83.

PINHO, D., MORATO, M., COUTO, M. R., MARQUES-LOPES, J., TAVARES, I. & ALBINO-TEIXEIRA, A. (2011). Does chronic pain alter the normal interaction between cardiovascular and pain regulatory systems? Pain modulation in the hypertensive-monoarthritic rat. J Pain, 12 (2), 194-204.

PINHO, M. J., CABRAL, J. M., SILVA, E., SERRAO, M. P. & SOARES-DA-SILVA, P. (2011). LAT1 overexpression and function compensates downregulation of ASCT2 in an in vitro model of renal proximal tubule cell ageing. Mol Cell Biochem, 349 (1-2), 107-16.

PINTO, V., AMARAL, J., SILVA, E., SIMAO, S., CABRAL, J. M., AFONSO, J., SERRAO, M. P., GOMES, P., PINHO, M. J. & SOARES-DA-SILVA, P. (2011). Age-related changes in the renal dopaminergic system and expression of renal amino acid transporters in WKY and SHR rats. Mech Ageing Dev, 132 (6-7), 298-304.

PINTO, V., PINHO, M. J., HOPFER, U., JOSE, P. A. & SOARES-DA-SILVA, P. (2011). Erratum to: Oxidative stress and the genomic regulation of aldosterone-stimulated NHE1 activity in SHR renal proximal tubular cells. Mol Cell Biochem,

QUINTAS, C., FRAGA, S., GONCALVES, J. & QUEIROZ, G. (2011). Opposite modulation of astroglial proliferation by adenosine 5'-O-(2-thio)-diphosphate and 2-methylthioadenosine-5'-diphosphate: mechanisms involved. Neuroscience, 182 32-42.

QUINTAS, C., FRAGA, S., GONCALVES, J. & QUEIROZ, G. (2011). P2Y receptors on astrocytes and microglia mediate opposite effects in astroglial proliferation. Purinergic Signal, 7 (2), 251-63.

RAMA, T. A., CORTE-REAL, I., GOMES, P. S., ESCRIBANO, L. & FERNANDES, M. H. (2011). Mastocytosis: oral implications of a rare disease. J Oral Pathol Med, 40 (6), 441-50.

RODRIGUES, S., PEREIRA, P., MAGRO, F., LOPES, S., ALBUQUERQUE, A., LOPES, J., CARNEIRO, F. & MACEDO, G. (2011). Dysplasia surveillance in an ulcerative colitis patient: successful detection with narrow band imaging and magnification. J Crohns Colitis, 5 (1), 54-6.

SA, M. C., RODRIGUES, R. P. & MOURA, D. (2011). [Carbon monoxide intoxications in Portugal]. Acta Med Port, 24 (5), 727-34.

SANTOS, L., FERRAZ, M. P., SHIROSAKI, Y., LOPES, M. A., FERNANDES, M. H., OSAKA, A. & SANTOS, J. D. (2011). Degradation studies and biological behavior on an artificial cornea material. Invest Ophthalmol Vis Sci, 52 (7), 4274-81.

SILVA, A., CAMPOS, S., MONTEIRO, J., VENANCIO, C., COSTA, B., GUEDES DE PINHO, P. & ANTUNES, L. (2011). Performance of anesthetic depth indexes in rabbits under propofol anesthesia: prediction probabilities and concentration-effect relations. Anesthesiology, 115 (2), 303-14.

SILVA, E., SERRAO, M. P. & SOARES-DA-SILVA, P. (2011). Age-dependent effect of ouabain on renal Na+,K+-ATPase. Life Sci, 88 (15-16), 719-24.

SILVA, E. & SOARES-DA-SILVA, P. (2011). Long-term regulation of Na+,K+-ATPase in opossum kidney cells by ouabain. J Cell Physiol, 226 (9), 2391-7.

SILVA, R. D., MANON, S., GONCALVES, J., SARAIVA, L. & CORTE-REAL, M. (2011). The importance of humanized yeast to better understand the role of bcl-2 family in apoptosis: finding of novel therapeutic opportunities. Curr Pharm Des, 17 (3), 246-55.

SIMAO, S., GOMES, P., PINHO, M. J. & SOARES-DA-SILVA, P. (2011). H2 O2 stimulates Cl- /HCO 3- exchanger activity through oxidation of thiol groups in immortalized SHR renal proximal tubular epithelial cells. J Cell Biochem, 112 (12), 3660-5.

SIMAO, S., GOMES, P., PINTO, V., SILVA, E., AMARAL, J. S., IGREJA, B., AFONSO, J., SERRAO, M. P., PINHO, M. J. & SOARES-DA-SILVA, P. (2011). Age-related changes in renal expression of oxidant and antioxidant enzymes and oxidative stress markers in male SHR and WKY rats. Exp Gerontol, 46 (6), 468-74.

SOUSA E SILVA, J. P., LOBO, J. S., BONIFACIO, M. J., MACHADO, R., FALCAO, A. & SOARES-DA-SILVA, P. (2011). In-vivo evaluation of prolonged release bilayer tablets of anti-Parkinson drugs in Gottingen minipigs. J Pharm Pharmacol, 63 (6), 780-5.

TALAIA, C., MORATO, M., QUINTAS, C., GONCALVES, J. & QUEIROZ, G. (2011). Functional crosstalk of prejunctional receptors on the modulation of noradrenaline release in mesenteric vessels: A differential study of artery and vein. Eur J Pharmacol, 652 (1-3), 33-9.

VAZ-DA-SILVA, M., NUNES, T., ROCHA, J. F., FALCAO, A., ALMEIDA, L. & SOARES-DA-SILVA, P. (2011). Effect of food on the pharmacokinetic profile of Etamicastat (BIA 5-453). Drugs R D, 11 (2), 127-36.

VIEIRA, C., FERREIRINHA, F., SILVA, I., DUARTE-ARAUJO, M. & CORREIA-DE-SA, P. (2011). Localization and function of adenosine receptor subtypes at the longitudinal muscle--myenteric plexus of the rat ileum. Neurochem Int, 59 (7), 1043-55.

BESSA PEREIRA, C., GOMES, P. S., COSTA-RODRIGUES, J., ALMEIDA PALMAS, R., VIEIRA, L., FERRAZ, M. P., LOPES, M. A. & FERNANDES, M. H. (2012). Equisetum arvense hydromethanolic extracts in bone tissue regeneration: in vitro osteoblastic modulation and antibacterial activity. Cell Prolif, 45 (4), 386-96.

BIALER, M. & SOARES-DA-SILVA, P. (2012). Pharmacokinetics and drug interactions of eslicarbazepine acetate. Epilepsia, 53 (6), 935-46.

CARVALHO, A., PELAEZ-VARGAS, A., GALLEGO-PEREZ, D., GRENHO, L., FERNANDES, M. H., DE AZA, A. H., FERRAZ, M. P., HANSFORD, D. J. & MONTEIRO, F. J. (2012). Micropatterned silica thin films with nanohydroxyapatite micro-aggregates for guided tissue regeneration. Dent Mater, 28 (12), 1250-60.

COELHO, J., NANDYALA, S. H., GOMES, P. S., SAMPAIO, P., PACHECO, A. P., NUNES, O. C., LOPES, M. A., FERNANDES, M. H. & SANTOS, J. D. (2012). Development and Characterization of Ag2O-Doped ZnLB Glasses and Biological Assessment of Ag2O-ZnLB-Hydroxyapatite Composites. Journal of the American Ceramic Society, 95 (9), 2732-2740.

COSTA, M., COSTA-RODRIGUES, J., FERNANDES, M. H., BARROS, P., VASCONCELOS, V. & MARTINS, R. (2012). Marine cyanobacteria compounds with anticancer properties: a review on the implication of apoptosis. Mar Drugs, 10 (10), 2181-207.

COSTA-RODRIGUES, J., CARMO, S. C., SILVA, J. C. & FERNANDES, M. H. (2012). Inhibition of human in vitro osteoclastogenesis by Equisetum arvense. Cell Prolif, 45 (6), 566-76.

COSTA-RODRIGUES, J., FERNANDES, A., LOPES, M. A. & FERNANDES, M. H. (2012). Hydroxyapatite surface roughness: complex modulation of the osteoclastogenesis of human precursor cells. Acta Biomater, 8 (3), 1137-45.

COSTA-RODRIGUES, J., MARTINS, E. G. & FERNANDES, M. H. (2012). Induced osteoclastogenesis by fluoroquinolones in unstimulated and stimulated human osteoclast precursor cells. Bone, 51 (1), 17-27.

COSTA-RODRIGUES, J., MONIZ, K. A., TEIXEIRA, M. R. & FERNANDES, M. H. (2012). Variability of the paracrine-induced osteoclastogenesis by human breast cancer cell lines. J Cell Biochem, 113 (3), 1069-79.

DIGNASS, A., ELIAKIM, R., MAGRO, F., MAASER, C., CHOWERS, Y., GEBOES, K., MANTZARIS, G., REINISCH, W., COLOMBEL, J. F., VERMEIRE, S., TRAVIS, S., LINDSAY, J. O. & VAN ASSCHE, G. (2012). Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 1: definitions and diagnosis. J Crohns Colitis, 6 (10), 965-90.

DURAO, S. F., GOMES, P. S., SILVA-MARQUES, J. M., FONSECA, H. R., CARVALHO, J. F., DUARTE, J. A. & FERNANDES, M. H. (2012). Bone regeneration in osteoporotic conditions: healing of subcritical-size calvarial defects in the ovariectomized rat. Int J Oral Maxillofac Implants, 27 (6), 1400-8.

ENELING, K., BRION, L., PINTO, V., PINHO, M. J., SZNAJDER, J. I., MOCHIZUKI, N., EMOTO, K., SOARES-DA-SILVA, P. & BERTORELLO, A. M. (2012). Salt-inducible kinase 1 regulates E-cadherin expression and intercellular junction stability. FASEB J, 26 (8), 3230-9.

FALCAO, A., FUSEAU, E., NUNES, T., ALMEIDA, L. & SOARES-DA-SILVA, P. (2012). Pharmacokinetics, drug interactions and exposure-response relationship of eslicarbazepine acetate in adult patients with partial-onset seizures: population pharmacokinetic and pharmacokinetic/pharmacodynamic analyses. CNS Drugs, 26 (1), 79-91.

FERNANDES, C., OLIVEIRA, L., TIRITAN, M. E., LEITAO, L., POZZI, A., NORONHA-MATOS, J. B., CORREIA-DE-SA, P. & PINTO, M. M. (2012). Synthesis of new chiral xanthone derivatives acting as nerve conduction blockers in the rat sciatic nerve. Eur J Med Chem, 55 1-11.

FONSECA, H., MOREIRA-GONCALVES, D., VAZ, M., FERNANDES, M. H., FERREIRA, R., AMADO, F., MOTA, M. P. & DUARTE, J. A. (2012). Changes in proximal femur bone properties following ovariectomy and their association with resistance to fracture. J Bone Miner Metab, 30 (3), 281-92.

FORTUNA, A., ALVES, G., ALMEIDA, A., LOPES, B., FALCAO, A. & SOARES-DA-SILVA, P. (2012). A chiral liquid chromatography method for the simultaneous determination of oxcarbazepine, eslicarbazepine, R-licarbazepine and other new chemical derivatives BIA 2-024, BIA 2-059 and BIA 2-265, in mouse plasma and brain. Biomed Chromatogr, 26 (3), 384-92.

FORTUNA, A., ALVES, G., FALCAO, A. & SOARES-DA-SILVA, P. (2012). Evaluation of the permeability and P-glycoprotein efflux of carbamazepine and several derivatives across mouse small intestine by the Ussing chamber technique. Epilepsia, 53 (3), 529-538.

FORTUNA, A., ALVES, G., SOARES-DA-SILVA, P. & FALCAO, A. (2012). Optimization of a parallel artificial membrane permeability assay for the fast and simultaneous prediction of human intestinal absorption and plasma protein binding of drug candidates: application to dibenz[b,f]azepine-5-carboxamide derivatives. J Pharm Sci, 101 (2), 530-40.

GARCIA, M. P., CAVALHEIRO, J. R. & FERNANDES, M. H. (2012). Acute and long-term effects of hyperthermia in B16-F10 melanoma cells. PLoS One, 7 (4), e35489.

GONCALVES, D., ALVES, G., SOARES-DA-SILVA, P. & FALCAO, A. (2012). Bioanalytical chromatographic methods for the determination of catechol-O-methyltransferase inhibitors in rodents and human samples: a review. Anal Chim Acta, 710 17-32.

GUIMARAES, H., GUEDES, M. B., ROCHA, G., TOME, T. & ALBINO-TEIXEIRA, A. (2012). Vitamin A in prevention of bronchopulmonary dysplasia. Curr Pharm Des, 18 (21), 3101-13.

GUIMARAES, J., MOURA, E., VIEIRA-COELHO, M. A. & GARRETT, C. (2012). Weight variation before and after surgery in Parkinson's disease: a noradrenergic modulation? Mov Disord, 27 (9), 1078-82.

LARANJEIRA, M. S., FERNANDES, M. H. & MONTEIRO, F. J. (2012). Reciprocal induction of human dermal microvascular endothelial cells and human mesenchymal stem cells: time-dependent profile in a co-culture system. Cell Prolif, 45 (4), 320-34.

MAGINA, S., CRUZ, M. J., AZEVEDO, F., MOURA, D., MOURA, E. & VIEIRA-COELHO, M. A. (2012). Narrowband ultraviolet B treatment for psoriasis increases serum vitamin A levels. Br J Dermatol, 167 (4), 958-60.

MAGINA, S., VIEIRA-COELHO, M. A., SERRAO, M. P., KOSMUS, C., MOURA, E. & MOURA, D. (2012). Ultraviolet B radiation differentially modifies catechol-O-methyltransferase activity in keratinocytes and melanoma cells. Photodermatol Photoimmunol Photomed, 28 (3), 137-41.

MAGRO, F., RODRIGUES, A., VIEIRA, A. I., PORTELA, F., CREMERS, I., COTTER, J., CORREIA, L., DUARTE, M. A., TAVARES, M. L., LAGO, P., MINISTRO, P., PEIXE, P., LOPES, S. & GARCIA, E. B. (2012). Review of the disease course among adult ulcerative colitis population-based longitudinal cohorts. Inflammatory Bowel Diseases, 18 (3), 573-583.

MARQUES, C., AMORIM, M. M., PEREIRA, J. O., PINTADO, M. E., MOURA, D., CALHAU, C. & PINHEIRO, H. (2012). Bioactive peptides: are there more antihypertensive mechanisms beyond ACE inhibition? Curr Pharm Des, 18 (30), 4706-13.

MARQUES, M., BROWN, S., CORREIA-SA, I., MN, D. S. C., RODRIGUES-PEREIRA, P., GONCALVES-RODRIGUES, A. & AMARANTE, J. (2012). The impact of triamcinolone acetonide in early breast capsule formation in a rabbit model. Aesthetic Plast Surg, 36 (4), 986-94.

MARQUES-LOPES, J., MARTINS, I., PINHO, D., MORATO, M., WILSON, S. P., ALBINO-TEIXEIRA, A. & TAVARES, I. (2012). Decrease in the expression of N-methyl-D-aspartate receptors in the nucleus tractus solitarii induces antinociception and increases blood pressure. J Neurosci Res, 90 (2), 356-66.

MASSANO, J. & GARRETT, C. (2012). Deep brain stimulation and cognitive decline in Parkinson's disease: a clinical review. Front Neurol, 3 66.

MOREIRA-RODRIGUES, M., QUELHAS-SANTOS, J., RONCON-ALBUQUERQUE, R., SERRAO, P., LEITE-MOREIRA, A., SAMPAIO-MAIA, B. & PESTANA, M. (2012). Blunted renal dopaminergic system in a mouse model of diet-induced obesity. Exp Biol Med (Maywood), 237 (8), 949-55.

MOURA, E., PINTO, C. E., SERRAO, M. P., AFONSO, J. & VIEIRA-COELHO, M. A. (2012). Adrenal alpha(2)-adrenergic receptors in the aging normotensive and spontaneously hypertensive rat. Neurobiology of Aging, 33 (5), 969-978.

MOURA, E., SILVA, E., SERRAO, M. P., AFONSO, J., KOZMUS, C. E. P. & VIEIRA-COELHO, M. A. (2012). alpha(2C)-Adrenoceptors modulate L-DOPA uptake in opossum kidney cells and in the mouse kidney. American Journal of Physiology-Renal Physiology, 303 (7), F928-F938.

NORONHA-MATOS, J. B., COSTA, M. A., MAGALHAES-CARDOSO, M. T., FERREIRINHA, F., PELLETIER, J., FREITAS, R., NEVES, J. M., SEVIGNY, J. & CORREIA-DE-SA, P. (2012). Role of ecto-NTPDases on UDP-sensitive P2Y(6) receptor activation during osteogenic differentiation of primary bone marrow stromal cells from postmenopausal women. J Cell Physiol, 227 (6), 2694-709.

OSORIO, F., MAGRO, F., LISBOA, C., LOPES, S., MACEDO, G., BETTENCOURT, H., AZEVEDO, F. & MAGINA, S. (2012). Anti-TNF-alpha induced psoriasiform eruptions with severe scalp involvement and alopecia: report of five cases and review of the literature. Dermatology, 225 (2), 163-7.

PALMA, P. N., BONIFACIO, M. J., LOUREIRO, A. I. & SOARES-DA-SILVA, P. (2012). Computation of the binding affinities of catechol-O-methyltransferase inhibitors: multisubstate relative free energy calculations. J Comput Chem, 33 (9), 970-86.

PEREIRA, C., LEAO, M., SOARES, J., BESSA, C. & SARAIVA, L. (2012). New therapeutic strategies for cancer and neurodegeneration emerging from yeast cell-based systems. Curr Pharm Des, 18 (27), 4223-35.

PEREIRA, M. W., CORREIA-DE-SA, P. & ALVES-DO-PRADO, W. (2012). Adenosine A(2A) receptor antagonists are broad facilitators of antinicotinic neuromuscular blockade monitored either with 2 Hz train-of-four or 50 Hz tetanic stimuli. Clin Exp Pharmacol Physiol, 39 (10), 869-77.

PINTO, V., PINHO, M. J., SILVA, E., SIMAO, S., IGREJA, B., AFONSO, J., SERRAO, M. P., GOMES, P. & SOARES-DA-SILVA, P. (2012). Long-term food restriction attenuates age-related changes in the expression of renal aldosterone-sensitive sodium transporters in Wistar-Kyoto rats: a comparison with SHR. Exp Gerontol, 47 (8), 644-53.

POPOV, S., VENETSANOU, K., CHEDRESE, P. J., PINTO, V., TAKEMORI, H., FRANCO-CERECEDA, A., ERIKSSON, P., MOCHIZUKI, N., SOARES-DA-SILVA, P. & BERTORELLO, A. M. (2012). Increases in intracellular sodium activate transcription and gene expression via the salt-inducible kinase 1 network in an atrial myocyte cell line. Am J Physiol Heart Circ Physiol, 303 (1), H57-65.

ROCHA, J. F., VAZ-DA-SILVA, M., NUNES, T., IGREJA, B., LOUREIRO, A. I., BONIFACIO, M. J., WRIGHT, L. C., FALCAO, A., ALMEIDA, L. & SOARES-DA-SILVA, P. (2012). Single-Dose Tolerability, Pharmacokinetics, and Pharmacodynamics of Etamicastat (BIA 5-453), a New Dopamine {beta}-Hydroxylase Inhibitor, in Healthy Subjects. Journal of clinical pharmacology, 52 156-170.

SAMPAIO-MAIA, B., FIGUEIRAL, M. H., SOUSA-RODRIGUES, P., FERNANDES, M. H. & SCULLY, C. (2012). The effect of denture adhesives on Candida albicans growth in vitro. Gerodontology, 29 (2), e348-56.

SANTOS, C., GOMES, P. S., DUARTE, J. A., FRANKE, R. P., ALMEIDA, M. M., COSTA, M. E. & FERNANDES, M. H. (2012). Relevance of the sterilization-induced effects on the properties of different hydroxyapatite nanoparticles and assessment of the osteoblastic cell response. J R Soc Interface, 9 (77), 3397-410.

SILVA, E. & SOARES-DA-SILVA, P. (2012). New insights into the regulation of Na+,K+-ATPase by ouabain. Int Rev Cell Mol Biol, 294 99-132.

SILVA, L. I. B., GOMES, A. M., PINTADO, M. M., PINHEIRO, H., MOURA, D., FREITAS, A. C., ROCHA-SANTOS, T. A. P., PEREIRA, M. E. & DUARTE, A. C. (2012). Optical Fiber Bioanalyzer Based on Enzymatic Coating Matrix for Catecholamines and Their Metabolites Assessment in Patients With Down Syndrome. IEEE Sensors Journal, 12 (1), 76-84.

SILVA, R. D., SARAIVA, L., COUTINHO, I., GONCALVES, J. & CORTE-REAL, M. (2012). Yeast as a powerful model system for the study of apoptosis regulation by protein kinase C isoforms. Curr Pharm Des, 18 (17), 2492-500.

SOUSA, T., OLIVEIRA, S., AFONSO, J., MORATO, M., PATINHA, D., FRAGA, S., CARVALHO, F. & ALBINO-TEIXEIRA, A. (2012). Role of H(2)O(2) in hypertension, renin-angiotensin system activation and renal medullary disfunction caused by angiotensin II. Br J Pharmacol, 166 (8), 2386-401.

VAZ-DA-SILVA, M., NUNES, T., ALMEIDA, L., GUTIERREZ, M. J., LITWIN, J. S. & SOARES-DA-SILVA, P. (2012). Evaluation of Eslicarbazepine Acetate on Cardiac Repolarization in a Thorough QT/QTc Study. Journal of clinical pharmacology, 52 222-233.

VIEIRA-COELHO, M. A. & MOURA, E. (2012). Effect of clonidine on renal sodium handling in spontaneously hypertensive rats. J Pharmacol Sci, 119 (2), 122-30.

VILAS-BOAS, F., MAGRO, F., BALHAU, R., LOPES, J. M., BECA, F., ELOY, C., LOPES, S. & MACEDO, G. (2012). Oral squamous cell carcinoma in a Crohn's disease patient taking azathioprine: case report and review of the literature. J Crohns Colitis, 6 (7), 792-5.

CORREIA-DE-SA, P., NORONHA-MATOS, J. B., TIMOTEO, M. A., FERREIRINHA, F., MARQUES, P., SOARES, A. M., CARVALHO, C., CAVALCANTE, W. L. & GALLACCI, M. (2013). Bothropstoxin-I reduces evoked acetylcholine release from rat motor nerve terminals: radiochemical and real-time video-microscopy studies. Toxicon, 61 16-25.